Researchers in Oxford University’s Department of Human Anatomy have identified a factor involved in the regeneration of neurons in the central nervous system. The discovery and use of this factor could provide the basis for a reparative treatment for both brain and spinal cord injuries.
Unlike lower vertebrates, mammals have lost the ability to repair damage to the brain and spinal cord. Since peripheral nerves are capable of repair, this is thought to be not so much an intrinsic inability of central nervous system (CNS) tissue to repair itself, but rather an environment in the CNS that is hostile to regeneration. This inhibition of neuronal regeneration is a result of a number of factors including axotomy-induced cell death, a gliotic scar that provides a physical barrier to regeneration as well as an environment that is inhibitory to growth. A number of strategies have been employed in the past to overcome this inhibition, including: blocking apoptosis, stem cell therapy, grafting of peripheral nervous system (PNS) cells and delivery of neurotrophic factors. However, the results of these animal studies have been controversial with regard to their claims of significant functional recovery.
Following a great deal of work on the action of Schwann cell conditioned medium (SCCM), which previous research has shown to support the re-growth of neuronal cells, the Oxford inventors have now identified a factor that is responsible for stimulation of neuronal re-growth and have demonstrated its effectiveness for both peripheral and central nervous system neurons. Use of this factor or its analogues may provide the basis for a reparative treatment for brain and spinal cord injury.
Jennifer Johnson | alfa
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
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25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
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A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
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At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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