Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sometimes no result is good result for science

28.03.2003


Sometimes finding out what doesn’t matter in science is just as important as finding what does.

That’s the case for a study that looked at the function of the viral protein, MTase1. Researchers found that the rate of virus replication in tissue culture was not affected when MTase1 was removed.

The finding is important as researchers look for what proteins are essential and how they function in cells, potentially providing answers to everything from insect control to the control of human diseases such as smallpox.



"How do viruses replicate? When there is an infection, one virus gets into one cell, and makes the cell synthesize viral proteins and viral DNA instead of what the cell needs to survive," said Dr. Linda Guarino, a Texas Agricultural Experiment Station biochemist and entomologist whose research with graduate student Xiaofeng Wu appears in this month’s Journal of Virology. "So, we want to understand how the virus manages to take over cells and force them to make more virus.

"We have to characterize the functions of individual viral proteins and how they interact with cellular proteins to understand this process," she noted.

Guarino and Wu studied MTase1 (methyltransferase) in the polyhedrosis virus of Autographa californica, a common moth species whose caterpillar feeds on alfalfa, sugar beets, tobacco and tomato crops. The insect has played an important role in research on viruses and their use as an environmentally friendly means of pest control, since the polyhedrosis virus was originally isolated from its larvae more than 30 years ago.

"MTase1 is structurally similar to a protein that poxvirus makes, and also in the poxvirus, it is non essential," Guarino said. "So, we know the virus makes proteins that are not essential when tested in a lab. However, we only studied replication in tissue culture, which is not the natural setting for replication. It might be essential in animals, so that will need to be researched as well."

She said the goal is to find out what proteins are essential, what they need to make RNA, and what their functions are.

Kathleen Phillips | Texas A&M University
Further information:
http://agnews.tamu.edu/dailynews/stories/BIOT/Mar2703a.htm

More articles from Life Sciences:

nachricht What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society

nachricht Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>