Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sometimes no result is good result for science

28.03.2003


Sometimes finding out what doesn’t matter in science is just as important as finding what does.

That’s the case for a study that looked at the function of the viral protein, MTase1. Researchers found that the rate of virus replication in tissue culture was not affected when MTase1 was removed.

The finding is important as researchers look for what proteins are essential and how they function in cells, potentially providing answers to everything from insect control to the control of human diseases such as smallpox.



"How do viruses replicate? When there is an infection, one virus gets into one cell, and makes the cell synthesize viral proteins and viral DNA instead of what the cell needs to survive," said Dr. Linda Guarino, a Texas Agricultural Experiment Station biochemist and entomologist whose research with graduate student Xiaofeng Wu appears in this month’s Journal of Virology. "So, we want to understand how the virus manages to take over cells and force them to make more virus.

"We have to characterize the functions of individual viral proteins and how they interact with cellular proteins to understand this process," she noted.

Guarino and Wu studied MTase1 (methyltransferase) in the polyhedrosis virus of Autographa californica, a common moth species whose caterpillar feeds on alfalfa, sugar beets, tobacco and tomato crops. The insect has played an important role in research on viruses and their use as an environmentally friendly means of pest control, since the polyhedrosis virus was originally isolated from its larvae more than 30 years ago.

"MTase1 is structurally similar to a protein that poxvirus makes, and also in the poxvirus, it is non essential," Guarino said. "So, we know the virus makes proteins that are not essential when tested in a lab. However, we only studied replication in tissue culture, which is not the natural setting for replication. It might be essential in animals, so that will need to be researched as well."

She said the goal is to find out what proteins are essential, what they need to make RNA, and what their functions are.

Kathleen Phillips | Texas A&M University
Further information:
http://agnews.tamu.edu/dailynews/stories/BIOT/Mar2703a.htm

More articles from Life Sciences:

nachricht Multifunctional bacterial microswimmer able to deliver cargo and destroy itself
26.04.2018 | Max-Planck-Institut für Intelligente Systeme

nachricht ADP-ribosylation on the right track
26.04.2018 | Max-Planck-Institut für Biologie des Alterns

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

European particle-accelerator community publishes the first industry compendium

26.04.2018 | Physics and Astronomy

Multifunctional bacterial microswimmer able to deliver cargo and destroy itself

26.04.2018 | Life Sciences

Why we need erasable MRI scans

26.04.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>