Using a laser beam scalpel so fine it could inscribe words on the surface of a fly egg, researchers have snipped their way to a new understanding of a key process in a fruit fly’s embryonic development. The process, called dorsal closure, is the complex mechanism by which the embryonic skin of the fruit fly Drosophila knits itself together to protect its innards from the outside world.
Understanding this seemingly arcane process is important because dorsal closure uses molecular and cellular mechanisms very similar to those involved in wound-healing as well as those that can go awry in humans to produce the spinal malformation spina bifida.
The researchers’ achievements were reported in an online article in the February 6, 2003, Sciencexpress -- and will appear in the April 4, 2003, print version of Science -- by an interdisciplinary Duke research team that includes biologists, physicists and a mathematician. It was this broad collaboration, said the scientists, that enabled them to refine the laser scalpel, to perform the microsurgery to dissect the fly tissue and to model the forces involved in key developmental machinery.
Dennis Meredith | EurekAlert!
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