Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel molecule may contribute to intestinal health

14.03.2003


New data suggests that a novel molecule appears to be involved in the intestine’s response to infection. The study was a collaboration between researchers at Washington University School of Medicine in St. Louis and the Institut Curie in Paris. It appears in the March 13 issue of the journal Nature.



“This is the first identified function for this molecule,” says co-senior author Susan Gilfillan, Ph.D., research instructor in pathology and immunology at the School of Medicine. “Our findings suggest that this molecule may play a fundamental role in gut immunology.”

When a virus enters the body, proteins called antigens appear on the surface of cells and alert the immune system to infection. A molecule called MR1, which was discovered eight years ago, appears to be very similar to the main category of molecules that deliver antigens to the cell surface, called major histocompatibility complex class I (MHC Class I). However, its function is not yet understood.


To learn more about MR1, Gilfillan and colleagues developed a strain of mice lacking the molecule. The mice failed to develop a small population of immune cells known as mucosal-associated invariant t cells (MAIT cells). MAIT cells were just recently discovered by the study’s other co-senior author, Olivier Lantz, Ph.D., at the Institut Curie in Paris. The current study presents the first extensive characterization of these cells.

“These results help us begin to understand the function of MR1 and the role of MAIT cells in immunology,” Gilfillan says. “Both are found not only in mice but also in humans and other animals, such as cows, which implies that they probably are very important.”

The team also discovered that MAIT cells appear to be primarily located in the mucous membrane of the intestine, or gut. Moreover, mice lacking bacteria normally found in the gut do not have MAIT cells.

From these results, Gilfillan and colleagues conclude that MAIT cells rely on both MR1 and intestinal bacteria. In addition, the results imply that MR1 and MAIT cells play a critical role in the intestine’s response to infection. The team plans to continue investigating these interactions and also to explore whether MR1 and MAIT are involved in fighting infections in other organs lined with mucous-producing cells, including the lungs.

“It’s possible that MR1 and MAIT cells are involved in a variety of diseases of the gut, particularly those relating to microorganisms that reside in the intestine,” Gilfillan says. “We also expect this line of research will be of particular interest for general mucosal immunology, and may prove useful in studying other organ systems as well.”


###
Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, Affaticati P, Gilfillan S, Lantz O. Selection of evolutionarily conserved mucosal-associated invariant T (MAIT) cells by MR1. Nature, March 13, 2003.

Funding from Association de la Recherche Contre la Cander, Fondation de la recherché Medicale, INSERM and Section Medicale de l’Institut Curie supported this research.

Gila Z. Reckess | EurekAlert!
Further information:
http://medinfo.wustl.edu/

More articles from Life Sciences:

nachricht Introduction of a novel system for in vitro analyses of zebrafish oligodendrocyte progenitor cells
23.10.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden

nachricht The birth of a new protein
20.10.2017 | University of Arizona

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Did you know how many parts of your car require infrared heat?

23.10.2017 | Automotive Engineering

3rd Symposium on Driving Simulation

23.10.2017 | Event News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>