Study featured on cover of the journal Nature
Hormones and neurotransmitters secreted from cells via bubble-like vesicles are released using age-related criteria, with the youngest vesicles getting first shot at releasing their contents, according to research led by a University of Southern California (USC) physiologist. This is a "complete reverse" from what had previously been presumed to be the process behind hormone secretion, notes Robert Chow, M.D., Ph.D., associate professor of physiology and biophysics at the Keck School of Medicine of USC, the studys principal investigator. In addition, he says, it now seems likely that upsetting this process may play a role in the development or progression of diseases of secretory cells, such as diabetes.
The research will be published as the cover story in the March 13 issue of the journal Nature, which will feature an image from the research paper representing the movement of a single vesicle over time, from docking at the cell membrane to release of its neurotransmitter.
Jon Weiner | EurekAlert!
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