Montreal Neurological Institute researcher Dr. Wayne Sossin has discovered that nerve cells can bypass the cell’s normal protein-making machinery in the same way that viruses do when they infect a cell. In a study published on-line today in Nature Neuroscience, Dr. Sossin and colleagues describe the first example of regulated IRES (internal ribosome entry site) usage after a physiological stimulus in neurons.
When a virus infects a cell, its goal is to make more virus particles. To do this, a virus takes over the cell’s protein making machinery (the ribosome), so that the cell essentially becomes a viral protein factory. It does this by using an internal ribosome entry site (IRES); which shuts down and bypasses the normal mechanisms that regulate binding of messenger RNAs to ribosomes. While many viral messenger RNAs are known to possess an IRES, few normal cellular RNAs do. Abnormal IRES regulation has been correlated with two human diseases- multiple myeloma and Charcot-Marie-Tooth disease. This is the first time that scientists have demonstrated that normal nerve cells can use an IRES to produce large quantities of protein under physiological conditions.
Dr. Sossin and colleagues made their discovery in a study of egg laying in the sea slug Aplysia. During egg laying, protein production of the egg laying hormone (ELH) increases dramatically. Sossin and colleagues discovered that the ELH messenger RNA contains an IRES. They demonstrated that after egg laying, nerve cells producing ELH switch from the normal cellular mechanism of protein production to one that uses the IRES. This switch allows for massive amounts of ELH protein to be produced at the expense of other cellular proteins, mimicking what a virus does when it infects a host cell.
Signaling Pathways to the Nucleus
19.03.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
In monogamous species, a compatible partner is more important than an ornamented one
19.03.2018 | Max-Planck-Institut für Ornithologie
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News