Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of MN researchers identify protein that causes cell nucleoli to disassemble

17.02.2003


Protein used during cell development important in cloning technique



Researchers at the University of Minnesota have identified the protein responsible for disassembly of donor nucleoli in the context of nuclear cloning. Although it was already known that nucleoli, essential structures for protein synthesis, normally disassemble or disappear for a period of time in the early animal development and also during nuclear cloning, it was not known until this study what causes this phenomenon. Researchers hope the identification of the protein will lead to advances in cloning techniques and potential therapies. The study will be published in the journal Nature Cell Biology on Feb. 17 (www.nature.com/ncb)

“The nucleolus, one of the largest structures found within the cell’s nucleus, contains numerous proteins that have essential roles in cell biology, for cancer, stem cells, and aging,” said lead researcher Nobuaki Kikyo, M.D, Ph.D., assistant professor of medicine, Stem Cell Institute. “By understanding how the nucleolus disassembles and reassembles, we hope to learn more about normal cell development, the roles of specific proteins, and their impact on human diseases.”


In the cloning process, the genetic material is removed from an egg cell, and then the nucleus containing the genetic material from a somatic (or body-associated) cell is transplanted into the egg cell. Kikyo and his team recreated the normal procedure by mixing somatic cell nuclei and protein extract from frog eggs to purify the proteins responsible for nucleolar disassembly. Kikyo identified the proteins, FRGY2a and FRGY2b, that disassemble nucleoli without help of other proteins. The nucleoli are later reassembled as they normally would be.

“The study shows that FRGY2 proteins may be able to transform adult cells into something more like embryonic cells—young and actively proliferating cells with flexibility to turn into many types of cells,” said Kikyo. “Furthermore, this work shows that it is possible to dissect the very mysterious process – cloning – with a biochemical approach and identify key players in it.”

Brenda Hudson | EurekAlert!
Further information:
http://www.umn.edu/

More articles from Life Sciences:

nachricht Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>