Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of MN researchers identify protein that causes cell nucleoli to disassemble

17.02.2003


Protein used during cell development important in cloning technique



Researchers at the University of Minnesota have identified the protein responsible for disassembly of donor nucleoli in the context of nuclear cloning. Although it was already known that nucleoli, essential structures for protein synthesis, normally disassemble or disappear for a period of time in the early animal development and also during nuclear cloning, it was not known until this study what causes this phenomenon. Researchers hope the identification of the protein will lead to advances in cloning techniques and potential therapies. The study will be published in the journal Nature Cell Biology on Feb. 17 (www.nature.com/ncb)

“The nucleolus, one of the largest structures found within the cell’s nucleus, contains numerous proteins that have essential roles in cell biology, for cancer, stem cells, and aging,” said lead researcher Nobuaki Kikyo, M.D, Ph.D., assistant professor of medicine, Stem Cell Institute. “By understanding how the nucleolus disassembles and reassembles, we hope to learn more about normal cell development, the roles of specific proteins, and their impact on human diseases.”


In the cloning process, the genetic material is removed from an egg cell, and then the nucleus containing the genetic material from a somatic (or body-associated) cell is transplanted into the egg cell. Kikyo and his team recreated the normal procedure by mixing somatic cell nuclei and protein extract from frog eggs to purify the proteins responsible for nucleolar disassembly. Kikyo identified the proteins, FRGY2a and FRGY2b, that disassemble nucleoli without help of other proteins. The nucleoli are later reassembled as they normally would be.

“The study shows that FRGY2 proteins may be able to transform adult cells into something more like embryonic cells—young and actively proliferating cells with flexibility to turn into many types of cells,” said Kikyo. “Furthermore, this work shows that it is possible to dissect the very mysterious process – cloning – with a biochemical approach and identify key players in it.”

Brenda Hudson | EurekAlert!
Further information:
http://www.umn.edu/

More articles from Life Sciences:

nachricht Molecular libraries for organic light-emitting diodes
24.04.2017 | Goethe-Universität Frankfurt am Main

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Molecular libraries for organic light-emitting diodes

24.04.2017 | Life Sciences

Research sheds new light on forces that threaten sensitive coastlines

24.04.2017 | Earth Sciences

Making lightweight construction suitable for series production

24.04.2017 | Machine Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>