Protein used during cell development important in cloning technique
Researchers at the University of Minnesota have identified the protein responsible for disassembly of donor nucleoli in the context of nuclear cloning. Although it was already known that nucleoli, essential structures for protein synthesis, normally disassemble or disappear for a period of time in the early animal development and also during nuclear cloning, it was not known until this study what causes this phenomenon. Researchers hope the identification of the protein will lead to advances in cloning techniques and potential therapies. The study will be published in the journal Nature Cell Biology on Feb. 17 (www.nature.com/ncb)
“The nucleolus, one of the largest structures found within the cell’s nucleus, contains numerous proteins that have essential roles in cell biology, for cancer, stem cells, and aging,” said lead researcher Nobuaki Kikyo, M.D, Ph.D., assistant professor of medicine, Stem Cell Institute. “By understanding how the nucleolus disassembles and reassembles, we hope to learn more about normal cell development, the roles of specific proteins, and their impact on human diseases.”
Brenda Hudson | EurekAlert!
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