Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Endothelial progenitor cells could serve as biological marker for cardiovascular disease

13.02.2003


The number of circulating endothelial progenitor cells in an individual’s blood –– the precursor cells to those that line the insides of blood vessels –– may be an indicator of overall cardiovascular health, according to research by scientists at the National Heart, Lung, and Blood Institute (NHLBI) and Emory University School of Medicine. The research was published in the Feb. 13 issue of the New England Journal of Medicine.



The endothelial cells lining the blood vessels provide essential communication between the vessels themselves and circulating blood cells, allowing the blood to flow smoothly. In diseases such as atherosclerosis, however, the endothelial layer becomes damaged and the vessels do not function efficiently. Until recently, scientists believed that nearby endothelial cells were recruited to help repair damaged blood vessels or form new ones to circumvent blocked vessels or to repair wounds. Evidence now shows, however, that endothelial progenitor cells, probably generated in the bone marrow, circulate in the bloodstream and are recruited to form new blood vessels or repair damaged ones.

The NHLBI and Emory scientists postulated that endothelial cells generated in the bone marrow contribute to continuous repair of the endothelial lining of blood vessels and that a lack of these cells can lead to vascular dysfunction and the progression of cardiovascular disease. They measured the number of "colony-forming units," or clumps, of endothelial progenitor cells in the peripheral blood of 45 men with a mean age of approximately 50 years. The men had various degrees of cardiovascular risk, but no history of cardiovascular disease. The researchers also measured blood vessel function using non-invasive high-resolution ultrasound of the brachial artery.


The research team calculated the subjects’ risk for cardiovascular disease using the Framingham risk factor score, commonly used to predict the risk of coronary artery disease in individuals without clinical disease. They found a significant inverse correlation between the number of circulating endothelial progenitor cells and the Framingham risk factor score. They also found a significant inverse correlation between the brachial artery measurement of vascular function and the number of circulating endothelial progenitor cells. The correlation between the brachial measurement of vascular function and the number of endothelial cells was stronger than it was between brachial function and conventional risk factors.

In order to test their hypothesis that endothelial progenitor cells age prematurely in individuals with higher cardiovascular risk factors, the investigators studied endothelial progenitor cells from subjects with either high or low Framingham risk scores. After seven days in culture, a significantly higher number of cells from the high-risk subjects had characteristics of senescence, or aging.

"Cardiovascular health is dependent on the ability of the blood vessels to continually repair themselves," says Arshed Quyyumi, MD, professor of medicine at Emory University School of Medicine, formerly of the NHLBI, and a member of the research team. "Evidence has shown that cardiovascular risk factors ultimately lead to damage to the endothelial layer of blood vessels. We can now speculate that continuing exposure to cardiovascular risk factors not only damages the endothelial layer, but may also lead to the depletion of circulating endothelial progenitor cells. Thus, the net damage to blood vessels and hence the risk of developing atherosclerosis depends not only on the exposure to risk factors, but also on the ability of the bone marrow-derived stem cells of endothelial origin to repair the damage.

"We will need larger studies to determine a definite cause and effect relationship between a decrease in these cells and adverse cardiovascular events. Our study did demonstrate, however, a correlation between endothelial progenitor cells, cardiovascular risk factors, increased senescence of endothelial progenitor cells, or stem cells, and vascular function. We are hopeful that further research will show that endothelial progenitor cells are a useful marker for cardiovascular disease risk."

Other members of the research team included Jonathan M. Hill, MRCP, Gloria Zalos, RN, Julian P.J. Halcox, MRCP, William H. Schenke, BA, Myron A. Waclawiw, PhD and Toren Finkel, MD, PhD, all of the NHLBI. The research was funded by the National Institutes of Health.

Ron Sauder | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Life Sciences:

nachricht Ambush in a petri dish
24.11.2017 | Friedrich-Schiller-Universität Jena

nachricht Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New proton record: Researchers measure magnetic moment with greatest possible precision

High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons

The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

IceCube experiment finds Earth can block high-energy particles from nuclear reactions

24.11.2017 | Physics and Astronomy

A 'half-hearted' solution to one-sided heart failure

24.11.2017 | Health and Medicine

Heidelberg Researchers Study Unique Underwater Stalactites

24.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>