In a significant scientific advance, researchers at the Department of Energy’s Pacific Northwest National Laboratory have identified or confirmed 490 proteins in human blood serum — nearly doubling the number of known serum proteins, according to a paper accepted for publication in the December issue of Molecular and Cellular Proteomics.
Using liquid chromatography and mass spectrometry instrumentation, Pacific Northwest National Laboratory scientists identified and characterized nearly twice as many proteins in blood serum than previously noted, which provides a greater library of proteins to study for potential use in disease diagnosis.
“We have performed the most extensive identification of proteins in serum to date,” said Joel Pounds, corresponding author and a PNNL staff scientist. “We studied blood serum because it holds clues to all the major processes in our bodies. We need to know what proteins exist in that serum to know how they might be used to predict disease susceptibility, monitor disease progression or diagnose disease.”
These clues include proteins that “leak” from dead and dying cells, and proteins secreted into blood or released from tumors. Identifying these proteins allows scientists to conduct additional studies to define each protein’s functional role in cells and the body.
Staci Maloof | EurekAlert!
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy