In a significant scientific advance, researchers at the Department of Energy’s Pacific Northwest National Laboratory have identified or confirmed 490 proteins in human blood serum — nearly doubling the number of known serum proteins, according to a paper accepted for publication in the December issue of Molecular and Cellular Proteomics.
Using liquid chromatography and mass spectrometry instrumentation, Pacific Northwest National Laboratory scientists identified and characterized nearly twice as many proteins in blood serum than previously noted, which provides a greater library of proteins to study for potential use in disease diagnosis.
“We have performed the most extensive identification of proteins in serum to date,” said Joel Pounds, corresponding author and a PNNL staff scientist. “We studied blood serum because it holds clues to all the major processes in our bodies. We need to know what proteins exist in that serum to know how they might be used to predict disease susceptibility, monitor disease progression or diagnose disease.”
These clues include proteins that “leak” from dead and dying cells, and proteins secreted into blood or released from tumors. Identifying these proteins allows scientists to conduct additional studies to define each protein’s functional role in cells and the body.
Staci Maloof | EurekAlert!
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
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An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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