Findings based on knock-out mice detailed in the journal Physiology and Behavior
A team led by University of Massachusetts Amherst researcher Deborah J. Good has identified a gene that appears to play a role in obesity, physical activity, and sex behaviors in mice. Good works with so-called "knock-out" mice, which have a specific gene deleted. Scientists then monitor the animals for changes in their physiology and behavior, in an effort to determine the genes role. Her findings are detailed in the current issue of the journal Physiology and Behavior. The project is funded with a four-year, $1 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, and a two-year, $70,000 grant from the National Institute of Child Health and Human Development, both of the National Institutes of Health.
Good is studying the mechanisms in the brain and nervous system that regulate appetite and body weight. Although more than 20 genes have been implicated in the regulation of body weight, the mechanisms through which these genes work remain unclear, she says. Recent evidence by Good suggests that a gene called Nhlh2 plays a key role in the regulation of genes controlling body weight, as well as physical activity levels and mating behavior.
Elizabeth Luciano | EurekAlert!
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