University of Minnesota researchers, with collaborators at the U. S. Department of Agricultures National Animal Disease Center in Ames, Iowa, have completed sequencing the genome of the bacteria that causes Johnes disease, a major chronic wasting disease found in dairy cattle. The bacterium, Mycobacterium paratuberculosis, is considered one of the most important threats to the health of dairy cattle worldwide and may represent a potential risk to the safety of the milk supply. The gene sequencing will allow researchers to develop new ways of early diagnosis, prevention and treatment of a disease that costs the dairy industry more than $200 million a year. The results of the sequencing analysis are available online at www.pathogenoics.umn.edu, and more about Johnes disease can be found at www.johnes.org.
"This is a horrible, hard to diagnose disease, largely because we lacked an understanding of the basic genetic makeup of the organism and the tools to differentiate the bacterium from other closely related species," said principal investigator Vivek Kapur, Ph.D., a faculty member in the University of Minnesota Medical School and College of Veterinary Medicine, director of the universitys Advanced Genetic Analysis Center and co-director of the Biomedical Genomics Center. "The genome sequence sheds new light on the genes and biochemical pathways in the bacterium, and the research offers a starting point for defining the mechanisms by which the organism causes disease and helping devise new strategies to detect infected animals and ultimately help control the spread of the organism."
M. paratuberculosis is a slow-growing bacterium that causes a chronic gastrointestinal infection in dairy cattle and other small ruminant species (such as sheep, goat, and deer) and has both serious health and economic consequences to dairy farming worldwide. While the bacterium has been recognized to cause Johnes disease for more than 100 years, methods for satisfactory diagnosis, treatment and prevention are lacking.
Deane Morrison | EurekAlert!
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy