Biologists at the Farber Institute for Neurosciences at Thomas Jefferson University have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinsons disease. If the researchers can better understand the process and harness this ability, the work may someday lead to new strategies in treating neurodegenerative diseases such as Parkinson’s.
Developmental biologist Lorraine Iacovitti, Ph.D., professor of neurology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, is searching for ways to convert stem cells into dopamine-making neurons to replace those lost in Parkinson’s. In previous work, she and her co-workers showed that mouse neural stem cells placed in rats with Parkinson’s disease could develop into brain cells that produced tyrosine hydroxylase (TH), the enzyme needed to make dopamine.
Dr. Iacovitti, who also is associate director of the Farber Institute for Neurosciences at Jefferson, wanted to see if human neural stem cells could become dopamine-producing brain cells as well. She and her colleagues grew neural stem cells in a laboratory dish. Using a cocktail of protein growth factors and nutrients, the researchers found they could coax approximately 25 percent of the stem cells to make TH in the dish, proving the stem cells had the capacity to manufacture dopamine. What’s more, when they removed the growth factor-cocktail, the cells continued to produce the enzyme. She reports her team’s findings November 5 at the annual meeting of the Society for Neuroscience in Orlando.
Steve Benowitz | EurekAlert!
Ambush in a petri dish
24.11.2017 | Friedrich-Schiller-Universität Jena
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons
The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
24.11.2017 | Physics and Astronomy
24.11.2017 | Health and Medicine
24.11.2017 | Earth Sciences