Two parts of the bodys immune system are critical for its normal functioning. One of these, the innate immune component, must defend the body against onslaughts from foreign substances it has never before seen. Failure of the immune system can result in cancer, autoimmune disease, or life threatening viral infections. Scientists at Memorial Sloan-Kettering Cancer Center have identified a gene called MEF that is essential to the development of Natural Killer cells and Natural Killer T-cells, which play a vital role in the innate immune system. Their findings are published as the cover study in the October 2002 issue of Immunity from Cell Press.
"By understanding how the MEF protein promotes the development and function of natural killer cells, we will develop ways to help the innate immune system better recognize and kill cancer cells," said Stephen D. Nimer, M.D., head of the Division of Hematology Oncology and the studys senior author. "We are planning future studies to learn how this can improve bone marrow transplant strategies."
"The differential regulation of perforin gene expression in the innate versus the adaptive immune system provides a selective target for future therapeutic interventions," explained H. Daniel Lacorazza, Ph.D., the studys first author.
Joanne Nicholas | EurekAlert!
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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