Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Solexa Announces Progress in its Single Molecule Array Technology at BioArrays Europe Conference


Speaking at BioArrays Europe (Cambridge, UK, 30 Sept-1 Oct), Dr Tony Smith, Chief Technology Officer (CTO) of Solexa, presented data on the progress of the Company`s proprietary Single Molecule Array™ technology for human genetic variation applications, highlighting significant progress in the massively parallel detection of single molecules using fluorescence.

Solexa’s Single Molecule Array technology is being applied to the measurement of individual genetic variation to develop a method for complete personal genome sequencing called TotalGenotyping™. The Company’s technical approach combines proprietary advances in synthetic chemistry, surface chemistry, molecular biology, enzymology, array technology, optics, and informatics. The aim is to offer a potential five order of magnitude efficiency improvement, well beyond the range possible from existing technologies.

Commenting on their progress Dr Tony Smith said: “The progress we have made in the massively parallel detection of single molecules using fluorescence is a fundamental step forward in applying our Single Molecule Array technology towards a full working prototype. These discoveries take the company one step further towards its ultimate goal of ‘the thousand dollar genome’.”

Unlike conventional high-density arrays, Single Molecule Arrays are unaddressed and monodispersed: the sites on the surface are randomly distributed and at each there is only one single molecule (a fragment of DNA in the case of the sequencing application). Because there is only a single molecule at each site, it is possible to create arrays of very high site density, around 108 sites per cm2 or more, allowing massively parallel processing. By working at the single molecule level, Solexa’s method also avoids the need for amplification of target sequence, allowing ‘one-pot’ sample preparation for a whole genome analysis. It is the combination of these two features of ultra-high site density and amplification-free, one-pot sample preparation that creates the breakthrough in economics and throughput.

Solexa’s goal is to determine individual sequence variation compared to a reference sequence, rather than de novo sequencing. Solexa is currently developing a proprietary sequencing chemistry, SmaSeq™, that is compatible with its Single Molecule Arrays, and is also developing a proprietary bioinformatics system that aligns the sequencing output reads in the context of a reference system.

Solexa intends to use the massively parallel character of its technology to enable measurement of virtually all variation in a sample sequence. Its technology makes it significantly more economical to measure all variation in a sample rather than to select any large subset for analysis. Given the highly significant value of the additional information generated by TotalGenotyping, this is an extremely compelling approach.

To reach full working prototype, Solexa scientists will work on the integration of the various components of its technology into a sequencing system over the next 12 months.

Caroline Stupnicka | alfa
Further information:

More articles from Life Sciences:

nachricht First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife

nachricht Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>