Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Solexa Announces Progress in its Single Molecule Array Technology at BioArrays Europe Conference

01.10.2002


Speaking at BioArrays Europe (Cambridge, UK, 30 Sept-1 Oct), Dr Tony Smith, Chief Technology Officer (CTO) of Solexa, presented data on the progress of the Company`s proprietary Single Molecule Array™ technology for human genetic variation applications, highlighting significant progress in the massively parallel detection of single molecules using fluorescence.



Solexa’s Single Molecule Array technology is being applied to the measurement of individual genetic variation to develop a method for complete personal genome sequencing called TotalGenotyping™. The Company’s technical approach combines proprietary advances in synthetic chemistry, surface chemistry, molecular biology, enzymology, array technology, optics, and informatics. The aim is to offer a potential five order of magnitude efficiency improvement, well beyond the range possible from existing technologies.

Commenting on their progress Dr Tony Smith said: “The progress we have made in the massively parallel detection of single molecules using fluorescence is a fundamental step forward in applying our Single Molecule Array technology towards a full working prototype. These discoveries take the company one step further towards its ultimate goal of ‘the thousand dollar genome’.”


Unlike conventional high-density arrays, Single Molecule Arrays are unaddressed and monodispersed: the sites on the surface are randomly distributed and at each there is only one single molecule (a fragment of DNA in the case of the sequencing application). Because there is only a single molecule at each site, it is possible to create arrays of very high site density, around 108 sites per cm2 or more, allowing massively parallel processing. By working at the single molecule level, Solexa’s method also avoids the need for amplification of target sequence, allowing ‘one-pot’ sample preparation for a whole genome analysis. It is the combination of these two features of ultra-high site density and amplification-free, one-pot sample preparation that creates the breakthrough in economics and throughput.

Solexa’s goal is to determine individual sequence variation compared to a reference sequence, rather than de novo sequencing. Solexa is currently developing a proprietary sequencing chemistry, SmaSeq™, that is compatible with its Single Molecule Arrays, and is also developing a proprietary bioinformatics system that aligns the sequencing output reads in the context of a reference system.

Solexa intends to use the massively parallel character of its technology to enable measurement of virtually all variation in a sample sequence. Its technology makes it significantly more economical to measure all variation in a sample rather than to select any large subset for analysis. Given the highly significant value of the additional information generated by TotalGenotyping, this is an extremely compelling approach.

To reach full working prototype, Solexa scientists will work on the integration of the various components of its technology into a sequencing system over the next 12 months.

Caroline Stupnicka | alfa
Further information:
http://www.solexa.com

More articles from Life Sciences:

nachricht Closing the carbon loop
08.12.2016 | University of Pittsburgh

nachricht Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>