Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Mapping Proteins: Researchers at Rensselaer Polytechnic Institute Discover a Better Way to Decode the Protein Language


Two researchers at Rensselaer Polytechnic Institute are creating a faster, more efficient data-mining technique to determine basic rules of how proteins form. The researchers are Mohammed Zaki, assistant professor of computer science, and Chris Bystroff, assistant professor of biology.

Researchers can identify a protein’s biological function, and therefore its specific role in disease, if they know the 3-D structure of a protein given its amino-acid sequence.

Twenty simple amino acids make up the "language" that forms the thousands of complex proteins in the human body. The idea is to discover how amino acids, or "letters," lead to "words" or common patterns to form proteins.

With that in mind, Zaki and Bystroff’s approach involves creating a 3-D image of each known protein already recorded in the worldwide Protein Data Bank. The researchers then reduce the image to a simpler 2-D representation, called a "contact map." The 2-D map reveals the chemical and other interactions among amino acids-data that are difficult to extract from the more complex 3-D images.

The data are mined from the contact map is then transferred into a knowledge bank of "contact rules" and used to predict unknown proteins and even how novel proteins might form.

The research is funded under a three-year, $333,928 Early Career Principal Investigator Award from the U.S. Department of Energy.

The research will appear in the IEEE (Institute of Electrical and Electronics Engineers) journal, Transactions on Systems, Man and Cybernetics in early 2003. The work will also appear in 2003 in a chapter of a book, called Handbook of Data Mining (Publisher: Lawrence Earlbaum Associates).

CONTACT: Mohammed Zaki (518) 276-6340,
Chris Bystroff (518) 276-3185,

Jodi Ackerman | Rensselaer News and Information

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>