Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mapping Proteins: Researchers at Rensselaer Polytechnic Institute Discover a Better Way to Decode the Protein Language

24.09.2002


Two researchers at Rensselaer Polytechnic Institute are creating a faster, more efficient data-mining technique to determine basic rules of how proteins form. The researchers are Mohammed Zaki, assistant professor of computer science, and Chris Bystroff, assistant professor of biology.



Researchers can identify a protein’s biological function, and therefore its specific role in disease, if they know the 3-D structure of a protein given its amino-acid sequence.

Twenty simple amino acids make up the "language" that forms the thousands of complex proteins in the human body. The idea is to discover how amino acids, or "letters," lead to "words" or common patterns to form proteins.


With that in mind, Zaki and Bystroff’s approach involves creating a 3-D image of each known protein already recorded in the worldwide Protein Data Bank. The researchers then reduce the image to a simpler 2-D representation, called a "contact map." The 2-D map reveals the chemical and other interactions among amino acids-data that are difficult to extract from the more complex 3-D images.

The data are mined from the contact map is then transferred into a knowledge bank of "contact rules" and used to predict unknown proteins and even how novel proteins might form.

The research is funded under a three-year, $333,928 Early Career Principal Investigator Award from the U.S. Department of Energy.

The research will appear in the IEEE (Institute of Electrical and Electronics Engineers) journal, Transactions on Systems, Man and Cybernetics in early 2003. The work will also appear in 2003 in a chapter of a book, called Handbook of Data Mining (Publisher: Lawrence Earlbaum Associates).

CONTACT: Mohammed Zaki (518) 276-6340, zaki@cs.rpi.edu
Chris Bystroff (518) 276-3185, bystrc@rpi.edu

Jodi Ackerman | Rensselaer News and Information

More articles from Life Sciences:

nachricht Closing in on advanced prostate cancer
13.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Visualizing single molecules in whole cells with a new spin
13.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

A whole-body approach to understanding chemosensory cells

13.12.2017 | Health and Medicine

Water without windows: Capturing water vapor inside an electron microscope

13.12.2017 | Physics and Astronomy

Cellular Self-Digestion Process Triggers Autoimmune Disease

13.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>