In findings they believe are fundamentally important to both biology and medicine, chemists at the University of North Carolina at Chapel Hill have shown experimentally for the first time that proteins can behave differently inside cells than when taken out of those cells and studied in test tubes.
"For 40 years, we thought we could learn most everything about proteins by studying them in water, but this work shows we are missing important observations by looking at them just in water or other solutions," said Dr. Gary Pielak, professor of chemistry and lead author of the study. "Our work demonstrates that we need to study them under the conditions they are found in inside the cell."
The research is relevant to medicine because the protein is related to proteins associated with Parkinsons and Alzheimers diseases and cancer, the scientists say.
David Williamson | EurekAlert!
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