Protein phosphatase 1 (PP1) belongs to a group of molecules that on the basis of earlier studies has been proposed to be a controlling factor for learning and memory. The ETH researchers produced genetically modified mice in which the activity of PP1 can be reduced at will. These animals were subjected to various learning and memory tests in one of which, the mice had to learn about various objects in a box. For this, they were trained on different schedules: without any interruption during learning or with short or long interruptions. To study how well the mice could remember the objects after learning, they were placed back into the box and one of the objects had been replaced with a novel object. If the animals explored the novel object significantly longer than the others, this was an indication that the mice remembered the familiar objects.
Protein Phosphatase 1 Makes Learning More Difficult
The tests showed that the mice with reduced PP1 and with short interruptions in the learning process achieved optimal performance that could be reached by control animals only with long interruptions. Isabelle Mansuy’s interpretation of these results is that “PP1 represents a necessary controlling factor, that is required to avoid saturation of the brain. Because the capacity of the brain is limited, it needs an active protective system”.
Prof. Isabelle Mansuy | alfa
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine