Scientists at the Department of Energys Pacific Northwest National Laboratory have obtained the most complete protein coverage of any organism to date with the study of a radiation-resistant microbe known to survive extreme environments. This research potentially could open up new opportunities to harness this microorganism, called Deinococcus radiodurans, for bioremediation.
A study published in the Aug. 20 issue of the Proceedings of the National Academy of Sciences observed a 61 percent coverage of the microbes possible predicted set of proteins, or its proteome. This is the most complete proteome reporting to date of any organism. (The proteome is the collection of proteins expressed by a cell under a specific set of conditions at a specific time.) PNNL scientists identified more than 1,900 proteins in D. radiodurans.
Studying the amount of each protein present at any time has become more important as scientists attempt to learn which proteins are involved in important cellular functions. DOEs Microbial Genome Program, an element of the Genomes to Life Program, provided the genomic information for various microorganisms, including D. radiodurans, and developed ways to predict the set of possible proteins, which hold the key to why and how these microbes carry out different functions.
Staci Maloof | EurekAlert!
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