Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method of oxidising terpenes holds exciting possibilities for perfumery, flavouring and pharmaceuticals

02.08.2002


Researchers in Oxford University¡¦s Department of Chemistry have devised a new method of selectively oxidising terpenes to produce compounds of particular interest to the perfumery, flavour and pharmaceutical industries.



Terpenes and their derivatives are commonly used in industry to modify flavours and fragrances, and new compounds for trial are continuously needed. The terpenes themselves are not of commercial interest, but rather the derivatives that commonly require stereoselective functionalisation at allylic as well as non-activated C-H bonds of the parent terpene. This is one of the most difficult reactions to carry out by conventional reactions since the highly reactive chemical oxidising agents are typically non-selective.

In the Oxford laboratory, considerable excitement is centred on the capability of introducing hydroxyl groups into specific sites in the molecule with a high degree of stereoselectivity. The researchers have developed a method of oxidising terpenes, or other hydrocarbons of interest, by enzymatic techniques. Indeed, non-activated C-H groups can be targeted. Typically, the oxidation produces high yields of relatively pure compounds.


The enzymes of particular interest are specific mutants of haem-containing enzymes, especially mutants of P450. Currently the mutant enzymes are expressed in E. coli as a host to produce an in vivo oxidation system which can be scaled up to large volumes. Initial work has demonstrated the oxidation of R-limonene to (+)-isopiperitenol or (+)-carveol depending on the enzyme and mutant, camphor to 5-exo-hydroxycamphor, (+)-Ą-pinene to (+)-verbenol and valencene to nootkatone.

Isis Innovation, Oxford University¡¦s technology transfer company, is actively seeking partners for the licensing and commercial development of this promising technology.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>