Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Unusual chromosomal changes increase the risk of schizophrenia

31.07.2008
People with schizophrenia have an increased number of unusual chromosomal changes, particularly structural changes that have the potential to alter the function of the genes. These results were published today in the scientific journal Nature.

Research scientists found changes in the structure of the genes in patients with schizophrenia when they studied what are known as copy number variants.

Genetic diseases are caused by a large number of different possible changes in human DNA. The type of mutation or change referred to as CNV means that large pieces of DNA may exist in several copies, have disappeared or have been transposed. In some diseases such changes in the genome may be protective, for example in HIV infection and malaria.

“The results strongly support the notion that schizophrenia may be partly caused by the effects of such structural changes in genes, both across the whole genome and in specific chromosomes,” says Christina Hultman, associate professor at Karolinska Institutet.

... more about:
»chromosomal »genes »schizophrenia

A breakthrough in genetic research on diabetes and prostate cancer, among other diseases, has been achieved in 2007 and 2008 by mapping the whole genome in what are known as genomwide association studies. There is now much to suggest that a breakthrough may also be made in schizophrenia in 2008, when up to seven studies relating to a total of 20,000 cases have been carried out. An important step will then be to understand the biological mechanisms underlying a complex pattern of genes that can be linked to schizophrenia and also what is known as epigenetics, that is to say how genes are switched on and off during the lifespan.

“We anticipate a breakthrough in the near future in research into psychiatric diseases such as schizophrenia, bipolar disease and autism. At the same I wish to stress that in such a complex disease as schizophrenia there is a need for research on both genetic and environmental causes and on treatment and management,” says Christina Hultman.

Schizophrenia is a common psychiatric disease. There are around 35,000 people in Sweden today who have at some time been in institutional care with the diagnosis of schizophrenia, and just as many who have been treated for other psychotic diseases.

It has long been known through family studies, adoption studies and twin studies that there appear to be hereditary causes of schizophrenia. The risk among both first-degree relatives (a person’s children) and second-degree relatives of people with schizophrenia is raised. The search for specific genetic causes in the last ten years has been intensive, but schizophrenia has a complex pattern of heredity, and the results of previous studies have been unclear. Various research teams have presented several different suggestions for genes that may be involved, including genes that control the development of brain cells.

Publication: “Rare chromosomal deletions and duplications increase risk of schizophrenia”, International Schizophrenia Consortium, which includes Christina Hultman from the Department of Medical Epidemiology and Biostatistics of Karolinska Institutet. Nature on line, www.nature.com, Digital Object Identifier (DOI): 10.1038/nature07239.

Sabina Bossi | alfa
Further information:
http://ki.se
http://ki.se/pressbilder

Further reports about: chromosomal genes schizophrenia

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>