Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cholesterol-lowering drug boosts bone repair

31.07.2008
Lovastatin, a drug used to lower cholesterol and help prevent cardiovascular disease, has been shown to improve bone healing in an animal model of neurofibromatosis type 1 (NF1).

The research, reported today in the open access journal BMC Medicine, will be of great interest to NF1 patients and their physicians.

Many NF1 patients suffer from bowing, spontaneous fractures and pseudarthrosis (incomplete healing) of the tibias (shinbones). Mateusz Kolanczyk from Stefan Mundlos’ laboratory in the Max Planck Institute for Molecular Genetics, Berlin, led a team that investigated lovastatin’s ability to prevent pseudarthrosis in a new animal model of human NF1 disease.

Current therapies are often futile when applied to pseudarthrosis of the tibia; in some cases, amputation is the only option. To better understand this problem, Kolanczyk and his colleagues developed this mouse model. He said, “In our model, the mice showed tibial bowing similar to that observed in NF1 patients, however since mouse legs are not subjected to the same excessive mechanical forces as humans, we also applied a bone injury model”. The authors drilled a 0.5mm hole in the tibia of anaesthetised mice. As they describe, “This enables analysis of the complex process of bone repair while at the same time causing the least possible distress to the animals”.

... more about:
»Drug »NF1 »healing »tibia

The process of bone repair was examined 7, 14 and 28 days post-injury. The authors found that the mice given the statin treatment had marked improvements in bone healing compared to the control animals. As they report, “Lovastatin appears to accelerate cortical bone repair primarily by enhancing new bone formation within the bone marrow cavity and by replacing fibro-cartilaginous tissue in the injury site with mineralised bone matrix”.

Kolanczyk concludes, “Our results suggest the usefulness of lovastatin, a drug approved in 1987 for the treatment of high cholesterol, in the treatment of neurofibromatosis-related fracture healing abnormalities”. The experimental model presented here constitutes a valuable tool for the preclinical testing of other candidate drugs that target similar bone problems.

Graeme Baldwin | alfa
Further information:
http://www.biomedcentral.com
http://www.biomedcentral.com/bmcmed/

Further reports about: Drug NF1 healing tibia

More articles from Life Sciences:

nachricht Ambush in a petri dish
24.11.2017 | Friedrich-Schiller-Universität Jena

nachricht Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New proton record: Researchers measure magnetic moment with greatest possible precision

High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons

The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

IceCube experiment finds Earth can block high-energy particles from nuclear reactions

24.11.2017 | Physics and Astronomy

A 'half-hearted' solution to one-sided heart failure

24.11.2017 | Health and Medicine

Heidelberg Researchers Study Unique Underwater Stalactites

24.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>