Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What do analytical chemicals do?

18.07.2008
Researchers from Rey Juan Carlos University and the University of Alcalá are developing analytical methodologies to quickly and efficiently evaluate asymmetric epoxidation processes of allyl alcohols.

Several industries, from pharmaceutical and chemical to food and others, require enantiomerically pure compounds for the development of their products. Enantiomers are non superposing specular images of a compound that has chiral properties. Many drugs contain chiral active compounds and in some cases, depending on the particular enantiomer used, the therapeutic effect may vary greatly.

This is the reason it is so important today to develop methods to produce enatiomers in a pure form; and also explains why the asymmetric synthesis procedures that produce only the desired enantiomer by means of a catalyst are now the focus of many investigations. Nevertheless, the great surge in development of this type of processes requires the parallel development of new analytical methods capable of evaluating the results obtained based on yield and enantiometric excess.

In 2001, the American chemist K.B. Sharpless was awarded the noble prize in chemistry for the development of a highly enantioselective process to obtain chiral epoxides from allyl alcohols using chiral titanium tartrate. This process is of great significance, since epoxides are widely used in organic synthesis processes as they are useful and versatile molecules that can suffer a large number of transformations due to their high reactivity. Examples can be found in ß-blockers, like Propranolol and for the synthesis of hepatitis B virus inhibitors.

... more about:
»Chiral »analytical »methods

The importance of these compounds and the constant research for new catalytic systems justify the need for the development of analytical methods that allow a simple, quick and efficient evaluation of these processes. For this reason, a research group at the Department of Inorganic and Analytical Chemistry at the Rey Juan Carlos University formed by the Doctors. S. Morante-Zarcero, I. del Hierro, M. Fajardo & I. Sierra, has developed and validated different analytical methods for the determination of such compounds by means of high efficiency liquid chromatography with ultraviolet detection and mass spectrometry (HPLC-DAD and HPLC-MS). Furthermore, in the last few years capillary electrophoresis (CE) has proved its great potential to carry out chiral separations. Thanks to its high efficiency, low reactive consumption and versatility, Professor. Mª Luisa Marina, in collaboration with Dr. Antonio Crego from the Department of Analytical Chemistry at the Alcalá University, applied this technique to develop the first methods using CE to determine chiral epoxides in this type of samples.

All the methodologies that were developed, and that have proven to have good characterising attributes, like linearity, precision, selectivity, detection limit, and quantification, have been used to successfully evaluate asymmetric epoxidation processes of allyl alcohols, using new chiral catalyst compounds based on titanium and have been published in analytical chemistry magazines such as the Journal of Chromatography A, Analytica Chimica Acta and Electrophoresis.

Oficina Información Científica | alfa
Further information:
http://www.madrimasd.org

Further reports about: Chiral analytical methods

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>