Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What do analytical chemicals do?

18.07.2008
Researchers from Rey Juan Carlos University and the University of Alcalá are developing analytical methodologies to quickly and efficiently evaluate asymmetric epoxidation processes of allyl alcohols.

Several industries, from pharmaceutical and chemical to food and others, require enantiomerically pure compounds for the development of their products. Enantiomers are non superposing specular images of a compound that has chiral properties. Many drugs contain chiral active compounds and in some cases, depending on the particular enantiomer used, the therapeutic effect may vary greatly.

This is the reason it is so important today to develop methods to produce enatiomers in a pure form; and also explains why the asymmetric synthesis procedures that produce only the desired enantiomer by means of a catalyst are now the focus of many investigations. Nevertheless, the great surge in development of this type of processes requires the parallel development of new analytical methods capable of evaluating the results obtained based on yield and enantiometric excess.

In 2001, the American chemist K.B. Sharpless was awarded the noble prize in chemistry for the development of a highly enantioselective process to obtain chiral epoxides from allyl alcohols using chiral titanium tartrate. This process is of great significance, since epoxides are widely used in organic synthesis processes as they are useful and versatile molecules that can suffer a large number of transformations due to their high reactivity. Examples can be found in ß-blockers, like Propranolol and for the synthesis of hepatitis B virus inhibitors.

... more about:
»Chiral »analytical »methods

The importance of these compounds and the constant research for new catalytic systems justify the need for the development of analytical methods that allow a simple, quick and efficient evaluation of these processes. For this reason, a research group at the Department of Inorganic and Analytical Chemistry at the Rey Juan Carlos University formed by the Doctors. S. Morante-Zarcero, I. del Hierro, M. Fajardo & I. Sierra, has developed and validated different analytical methods for the determination of such compounds by means of high efficiency liquid chromatography with ultraviolet detection and mass spectrometry (HPLC-DAD and HPLC-MS). Furthermore, in the last few years capillary electrophoresis (CE) has proved its great potential to carry out chiral separations. Thanks to its high efficiency, low reactive consumption and versatility, Professor. Mª Luisa Marina, in collaboration with Dr. Antonio Crego from the Department of Analytical Chemistry at the Alcalá University, applied this technique to develop the first methods using CE to determine chiral epoxides in this type of samples.

All the methodologies that were developed, and that have proven to have good characterising attributes, like linearity, precision, selectivity, detection limit, and quantification, have been used to successfully evaluate asymmetric epoxidation processes of allyl alcohols, using new chiral catalyst compounds based on titanium and have been published in analytical chemistry magazines such as the Journal of Chromatography A, Analytica Chimica Acta and Electrophoresis.

Oficina Información Científica | alfa
Further information:
http://www.madrimasd.org

Further reports about: Chiral analytical methods

More articles from Life Sciences:

nachricht Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University

nachricht Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>