These two illnesses also share genetic variants that might be involved in the predisposition to both disorders. A new study scheduled for publication in the July 15th issue of Biological Psychiatry sought to analyze the patterns of gene expression in the brains of individuals diagnosed with one of these disorders to search for a common “characteristic [genetic] signature.”
Using microarray gene expression, Drs. Ling Shao and Marquis Vawter tested whether there was a core set of genes shared in the predisposition or long term consequences of both illnesses. The researchers found 78 dysregulated genes, representing genes involved in nervous system development and cell death, which displayed differential expression compared to control subjects. As Dr. Vawter further explains, “the pattern of dysregulation was similar in the prefrontal cortex for both illnesses and pointed to key processes. Part of the set of core genes could be explained by medication responses; however most of these core genes did not appear to be correlated to medication response.”
John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds: “The new findings by Drs. Shao and Vawter provide evidence that there are a large number of genes that show a similar pattern of abnormal regulation in their sample of post-mortem brain tissue from individuals who had been diagnosed with schizophrenia or bipolar disorder. This overlap could provide insight into the neurobiology of both disorders.” Better understanding of the neurobiology related to the shared genes may offer a window into discovery of common brain mechanism(s) that could guide the identification of new and more effective treatments.
The authors also mention in their article recent discussions that have focused on considering schizophrenia and bipolar disorder as a single illness viewed along a continuum of mood and psychotic symptoms. Dr. Krystal concurs, noting that “we have traditionally treated these diagnoses as unrelated conditions even though many of the same medications, such as antipsychotic medications, are used to treat both conditions.” Thus, there may be a need for our understanding of psychiatric diagnoses to evolve to fit the growing support of some common disease-related mechanisms that cross diagnostic boundaries, as evidenced by the findings in this study.
Jayne Dawkins | alfa
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
21.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Matabele ants: Travelling faster with detours
21.05.2018 | Julius-Maximilians-Universität Würzburg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology