These two illnesses also share genetic variants that might be involved in the predisposition to both disorders. A new study scheduled for publication in the July 15th issue of Biological Psychiatry sought to analyze the patterns of gene expression in the brains of individuals diagnosed with one of these disorders to search for a common “characteristic [genetic] signature.”
Using microarray gene expression, Drs. Ling Shao and Marquis Vawter tested whether there was a core set of genes shared in the predisposition or long term consequences of both illnesses. The researchers found 78 dysregulated genes, representing genes involved in nervous system development and cell death, which displayed differential expression compared to control subjects. As Dr. Vawter further explains, “the pattern of dysregulation was similar in the prefrontal cortex for both illnesses and pointed to key processes. Part of the set of core genes could be explained by medication responses; however most of these core genes did not appear to be correlated to medication response.”
John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds: “The new findings by Drs. Shao and Vawter provide evidence that there are a large number of genes that show a similar pattern of abnormal regulation in their sample of post-mortem brain tissue from individuals who had been diagnosed with schizophrenia or bipolar disorder. This overlap could provide insight into the neurobiology of both disorders.” Better understanding of the neurobiology related to the shared genes may offer a window into discovery of common brain mechanism(s) that could guide the identification of new and more effective treatments.
The authors also mention in their article recent discussions that have focused on considering schizophrenia and bipolar disorder as a single illness viewed along a continuum of mood and psychotic symptoms. Dr. Krystal concurs, noting that “we have traditionally treated these diagnoses as unrelated conditions even though many of the same medications, such as antipsychotic medications, are used to treat both conditions.” Thus, there may be a need for our understanding of psychiatric diagnoses to evolve to fit the growing support of some common disease-related mechanisms that cross diagnostic boundaries, as evidenced by the findings in this study.
Jayne Dawkins | alfa
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
18.10.2017 | Health and Medicine
18.10.2017 | Life Sciences
17.10.2017 | Life Sciences