The tumour cells can disseminate into the organism by using the blood or lymphatic stream. Recent data suggest that the site of implantation of secondary foci or metastases is preset by the elaboration of an appropriate microenvironment.
These novel information led to the emerging concept of “premetastatic niche”. In addition, cancer cells must acquire new properties ensuring their mobility and the invasion of various tissues. Cancer stem cells are thought to constitute the proliferative potential of the tumoral mass and could represent the source of cells metastasizing.
The tumour cell-centrered view of the metastatic process is now revisited taking into account the important contribution of the tumor microenvironment consisting of both cellular and non cellular components, in primary tumors as well as in secondary foci.
A new European network, entitled MICROENVIMET, developed within the 7th EU framework is coordinated by Professor Agnès NOEL (Laboratory of Tumour and the Development Biology, GIGA-Cancer research center of the University of Liege, Belgium). This European scientific network entitled “Microenvimet: Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network” (http://www.microenvimet.eu) gathers 8 international partners. It is funded to the amount of 2.999.689 euro for 4 years by the European commission.
The purpose of the project “microenvimet” is to elucidate and understand the early mechanisms of the metastatic dissemination by studying the contribution of tumour microenvironment during various stages of epithelial cancer evolution: the primary tumour growth, the premetastatic phase preceding the dissemination of the cancer cells and the metastatic phase during which the secondary foci develop. It aims at identifying molecular targets contributing to early steps of the tumour progression. The project is focused on the mechanisms underlying the elaboration of a favorable «soil » for the establishment of metastases (“premetastatic niche”).
Its original approach consists in modifying the tumoral microenvironment, interfering with proteases which constitute important regulators of the interactions which are established between tumoral cells and their cellular and molecular microenvironment. This project is based on the exploitation of innovating technological platforms: genomic platform for the analysis of the RNA messengers and the recently identified microRNA, phage library for the development of blocking antibodies against the identified targets, platform of computer-assisted image analysis and transgenesis platform.
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At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
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A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
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