The tumour cells can disseminate into the organism by using the blood or lymphatic stream. Recent data suggest that the site of implantation of secondary foci or metastases is preset by the elaboration of an appropriate microenvironment.
These novel information led to the emerging concept of “premetastatic niche”. In addition, cancer cells must acquire new properties ensuring their mobility and the invasion of various tissues. Cancer stem cells are thought to constitute the proliferative potential of the tumoral mass and could represent the source of cells metastasizing.
The tumour cell-centrered view of the metastatic process is now revisited taking into account the important contribution of the tumor microenvironment consisting of both cellular and non cellular components, in primary tumors as well as in secondary foci.
A new European network, entitled MICROENVIMET, developed within the 7th EU framework is coordinated by Professor Agnès NOEL (Laboratory of Tumour and the Development Biology, GIGA-Cancer research center of the University of Liege, Belgium). This European scientific network entitled “Microenvimet: Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network” (http://www.microenvimet.eu) gathers 8 international partners. It is funded to the amount of 2.999.689 euro for 4 years by the European commission.
The purpose of the project “microenvimet” is to elucidate and understand the early mechanisms of the metastatic dissemination by studying the contribution of tumour microenvironment during various stages of epithelial cancer evolution: the primary tumour growth, the premetastatic phase preceding the dissemination of the cancer cells and the metastatic phase during which the secondary foci develop. It aims at identifying molecular targets contributing to early steps of the tumour progression. The project is focused on the mechanisms underlying the elaboration of a favorable «soil » for the establishment of metastases (“premetastatic niche”).
Its original approach consists in modifying the tumoral microenvironment, interfering with proteases which constitute important regulators of the interactions which are established between tumoral cells and their cellular and molecular microenvironment. This project is based on the exploitation of innovating technological platforms: genomic platform for the analysis of the RNA messengers and the recently identified microRNA, phage library for the development of blocking antibodies against the identified targets, platform of computer-assisted image analysis and transgenesis platform.
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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