The tumour cells can disseminate into the organism by using the blood or lymphatic stream. Recent data suggest that the site of implantation of secondary foci or metastases is preset by the elaboration of an appropriate microenvironment.
These novel information led to the emerging concept of “premetastatic niche”. In addition, cancer cells must acquire new properties ensuring their mobility and the invasion of various tissues. Cancer stem cells are thought to constitute the proliferative potential of the tumoral mass and could represent the source of cells metastasizing.
The tumour cell-centrered view of the metastatic process is now revisited taking into account the important contribution of the tumor microenvironment consisting of both cellular and non cellular components, in primary tumors as well as in secondary foci.
A new European network, entitled MICROENVIMET, developed within the 7th EU framework is coordinated by Professor Agnès NOEL (Laboratory of Tumour and the Development Biology, GIGA-Cancer research center of the University of Liege, Belgium). This European scientific network entitled “Microenvimet: Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network” (http://www.microenvimet.eu) gathers 8 international partners. It is funded to the amount of 2.999.689 euro for 4 years by the European commission.
The purpose of the project “microenvimet” is to elucidate and understand the early mechanisms of the metastatic dissemination by studying the contribution of tumour microenvironment during various stages of epithelial cancer evolution: the primary tumour growth, the premetastatic phase preceding the dissemination of the cancer cells and the metastatic phase during which the secondary foci develop. It aims at identifying molecular targets contributing to early steps of the tumour progression. The project is focused on the mechanisms underlying the elaboration of a favorable «soil » for the establishment of metastases (“premetastatic niche”).
Its original approach consists in modifying the tumoral microenvironment, interfering with proteases which constitute important regulators of the interactions which are established between tumoral cells and their cellular and molecular microenvironment. This project is based on the exploitation of innovating technological platforms: genomic platform for the analysis of the RNA messengers and the recently identified microRNA, phage library for the development of blocking antibodies against the identified targets, platform of computer-assisted image analysis and transgenesis platform.
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24.03.2017 | Forschungsverbund Berlin e.V.
When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Health and Medicine
24.03.2017 | Earth Sciences