Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain ‘trick’ offers treatment hope for Alzheimer’s

03.07.2008
Scientists in the UK and Canada have made a significant step forward in the search for new drugs to treat Alzheimer’s disease.

An ageing population means that neurodegeneration, such as Alzheimer’s disease, is one of the major health problems in the developed world. But researchers at the University of York and Simon Fraser University in Burnaby, British Columbia, have designed an enzyme inhibitor which could ‘trick’ the brain and so help to halt neurodegeneration.

The research is published in the latest issue of Nature Chemical Biology.

One of the causes of neurodegeneration is a modification to the protein ‘tau’, which helps to maintain the stability of neurones in the brain, causing them to form aggregates termed ‘tangles’.

... more about:
»Alzheimer »Tau »enzyme

These diseases, or ‘tauopathies’ are believed to be caused by a form of the protein tau which has been excessively modified with phosphate.

By studying the chemistry and structure of relevant enzymes, the research teams at York, led by Professor Gideon Davies, and Simon Fraser, led by Professor David Vocadlo, have designed an enzyme inhibitor that prevents the phosphorylation of tau in animal models. They have effectively tricked the brain’s own enzymes into installing a sugar on to tau in place of the detrimental phosphates.

The enzyme inhibitor, termed a ‘thiazoline’, developed by Professor Vocadlo and Professor Davies is not yet a drug, but it is a major breakthrough in finding compounds that cross the blood-brain barrier to elicit beneficial effects that prevent the onset of tauopathies.

Professor Davies, of the Department of Chemistry at York, said: “We hope that the work will evolve into new drugs to treat Alzheimer’s disease, although that is still many years off. The work highlights the synergy of studying the chemistry of enzymes in living cells.”

The York /Simon Fraser collaboration also revealed the first structure of the enzyme responsible for the installation of these protective sugars in a paper in Nature Structural & Molecular Biology earlier this month.

David Garner | alfa
Further information:
http://www.york.ac.uk
http://www.york.ac.uk/admin/presspr/pressreleases/alzheimersresearch.htm

Further reports about: Alzheimer Tau enzyme

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>