Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain ‘trick’ offers treatment hope for Alzheimer’s

03.07.2008
Scientists in the UK and Canada have made a significant step forward in the search for new drugs to treat Alzheimer’s disease.

An ageing population means that neurodegeneration, such as Alzheimer’s disease, is one of the major health problems in the developed world. But researchers at the University of York and Simon Fraser University in Burnaby, British Columbia, have designed an enzyme inhibitor which could ‘trick’ the brain and so help to halt neurodegeneration.

The research is published in the latest issue of Nature Chemical Biology.

One of the causes of neurodegeneration is a modification to the protein ‘tau’, which helps to maintain the stability of neurones in the brain, causing them to form aggregates termed ‘tangles’.

... more about:
»Alzheimer »Tau »enzyme

These diseases, or ‘tauopathies’ are believed to be caused by a form of the protein tau which has been excessively modified with phosphate.

By studying the chemistry and structure of relevant enzymes, the research teams at York, led by Professor Gideon Davies, and Simon Fraser, led by Professor David Vocadlo, have designed an enzyme inhibitor that prevents the phosphorylation of tau in animal models. They have effectively tricked the brain’s own enzymes into installing a sugar on to tau in place of the detrimental phosphates.

The enzyme inhibitor, termed a ‘thiazoline’, developed by Professor Vocadlo and Professor Davies is not yet a drug, but it is a major breakthrough in finding compounds that cross the blood-brain barrier to elicit beneficial effects that prevent the onset of tauopathies.

Professor Davies, of the Department of Chemistry at York, said: “We hope that the work will evolve into new drugs to treat Alzheimer’s disease, although that is still many years off. The work highlights the synergy of studying the chemistry of enzymes in living cells.”

The York /Simon Fraser collaboration also revealed the first structure of the enzyme responsible for the installation of these protective sugars in a paper in Nature Structural & Molecular Biology earlier this month.

David Garner | alfa
Further information:
http://www.york.ac.uk
http://www.york.ac.uk/admin/presspr/pressreleases/alzheimersresearch.htm

Further reports about: Alzheimer Tau enzyme

More articles from Life Sciences:

nachricht What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society

nachricht Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>