Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Splenic ellipsoids might be significant in the early development of AA amyloidosis

26.06.2008
During the course of her PhD studies, Randi Sørby demonstrated that ellipsoids, small filtering units for blood in the spleen, might be significant in the development of AA amyloidosis.

AA amyloidosis is a potential complication of chronic inflammation or infection, for example, rheumatoid arthritis and tuberculosis, and is characterised by systematic deposition of protein fibrils in the tissues of organs such as the spleen and liver. Similar deposition, but of other proteins, also occurs in diseases such as Alzheimer's disease, Parkinson’s disease, and prion-associated disease ("mad cow disease").

In her thesis, Randi Sørby used experimental amyloidosis in the mink as a model to study how amyloid deposition arises in different parts of the spleen. This model was chosen because the mink has especially well-developed ellipsoids, which are lacking in the more commonly-used experimental animals such as mouse and rat, but which are found in most other mammals, including man. Studies have shown that ellipsoids are central structures in amyloid deposition and that they play an early role in the development of the disease.

In addition to amyloid fibrils, other proteins have been demonstrated (amyloid P component and apolipoproteins) and long polysaccharides (glycosaminoglycans)that may also be significant for the development of the depositions. One particularly interesting find was that several of these molecules were already present normally in the ellipsoids, which may help to explain why ellipsoids are involved so early.

... more about:
»Amyloid »Sørby »amyloidosis »ellipsoids »mink »significant

The structure and general functions of ellipsoids were also studied. Sørby showed that ellipsoids also in mink are an effective filter of blood plasma. Various substances injected into the blood, such as carbon particles, small plastic spheres, and antigen-antibody complexes, were effectively removed by cells in the wall of the ellipsoids. These filtering qualities very likely play a role in he the development of the amyloid depositions.

The experimental model of amyloidosis in the mink has been further refined by injecting an extract of amyloid-containing tissue ("amyloid enhancing factor"). In this method, amyloid deposition develops significantly faster and shows a more predictable progression. This will enable future studies of the ellipsoid's role in the earliest phases of amyloidosis development.

Cand. med. vet. Randi Sørby defended her thesis for the degree of Philosophiae Doctor(PhD) on May 30, 2008, with the title "The involvement of splenic microenvironments, with emphasis on the ellipsoids, in experimental AA amyloidosis in mink."

The work was carried out at the Department of Basic Sciences & Aquatic Medicine of the Norwegian School of Veterinary Science, and was a collaboration with Dr. med. Tale Nordbye Wien and Professor Gunnar Husby of the Rikshospitalet University Hospital HF.

Magnhild Jenssen | alfa
Further information:
http://www.veths.no
http://www.veths.no/105/English/Kima/Splenic-ellipsoids-might-be-significant-in-the-early-development-of-AA-amyloidosis/

Further reports about: Amyloid Sørby amyloidosis ellipsoids mink significant

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Periodic ventilation keeps more pollen out than tilted-open windows

29.03.2017 | Health and Medicine

Researchers discover dust plays prominent role in nutrients of mountain forest ecoystems

29.03.2017 | Earth Sciences

OLED production facility from a single source

29.03.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>