An electric voltage can be used to propel DNA molecules through a channel a few nanometers deep, or to stop them in their tracks.
In a strong electric field the molecules judder along the channel, while in weaker fields they move more smoothly. This enables DNA fragments to be ‘captured’ on a chip and separated for analysis. University of Twente researchers will soon publish details of this work in Nano Letters.
The researchers found that, when forced through extremely shallow channels just 20 nanometers deep and a few micrometers wide, DNA molecules behave very differently than they do in free solution. In the latter situation they tend to form clumps, while molecules in the channels are forced into an elongated straitjacket.
This effect alone produces a difference in mobility between long and short molecules. Moreover, exposure to an electric field has now been shown to have a substantial effect. This presents a range of new options for the separation of fragments (and entire molecules) of DNA. The previous technique, known as gel electrophoresis, involved the use of micro-channels filled with a gel.
According to researcher Georgette Salieb-Beugelaar, the laborious and time-consuming process of pouring in the gel can be rendered obsolete by the new method.Roughness
Wiebe van der Veen | alfa
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
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20.10.2017 | Interdisciplinary Research