An electric voltage can be used to propel DNA molecules through a channel a few nanometers deep, or to stop them in their tracks.
In a strong electric field the molecules judder along the channel, while in weaker fields they move more smoothly. This enables DNA fragments to be ‘captured’ on a chip and separated for analysis. University of Twente researchers will soon publish details of this work in Nano Letters.
The researchers found that, when forced through extremely shallow channels just 20 nanometers deep and a few micrometers wide, DNA molecules behave very differently than they do in free solution. In the latter situation they tend to form clumps, while molecules in the channels are forced into an elongated straitjacket.
This effect alone produces a difference in mobility between long and short molecules. Moreover, exposure to an electric field has now been shown to have a substantial effect. This presents a range of new options for the separation of fragments (and entire molecules) of DNA. The previous technique, known as gel electrophoresis, involved the use of micro-channels filled with a gel.
According to researcher Georgette Salieb-Beugelaar, the laborious and time-consuming process of pouring in the gel can be rendered obsolete by the new method.Roughness
Wiebe van der Veen | alfa
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
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21.10.2016 | Health and Medicine
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21.10.2016 | Materials Sciences