Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crucial Factors in Lymphoma Development and Survival Discovered

24.06.2008
Experiments with new mouse model suggest therapeutic targets

Researchers at National Jewish Medical and Research Center have discovered an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer. The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas.

The research team, led by Yosef Refaeli, PhD, Assistant Professor of Pediatrics at National Jewish Medical and Research Center , also showed that disruption of signals from the B-cell receptor can inhibit growth of the tumors. The research is being published in the June 24 issue of the journal, PLos Biology.

“Non-hodgkins lymphomas, about 90 percent of which are B-cell lymphomas, have become 85 percent more prevalent in the past 20 years, the only major form of cancer to experience such growth” said Dr. Refaeli. “Our findings have pointed to the B-cell receptor and its signaling pathways as very promising therapeutic targets for B-cell lymphomas.”

... more about:
»Antigen »B cells »B-cell »Myc »Refaeli »lymphoma

Non-Hodgkins lymphoma is a cancer of lymphocytes, immune system cells known as T cells and B cells. About 66,000 new cases of non-Hodgkins lymphoma are diagnosed each year in the United States , and about 19,000 people die of it.

It has long been known that the oncogene MYC plays a crucial role in the development of lymphomas. One unanswered question, however, is whether the B-cell receptor on the surface of B cells, may also play an important role.

When the B-cell receptor binds to molecules on foreign invaders, known as antigens, it sends a signal that causes the B cells to proliferate and produce antibodies. The antibodies bind to the foreign molecules and mark the invaders for destruction. Even if it doesn’t bind to an antigen, the B-cell receptor promotes the survival of B cells through an unknown intracellular signal.

Dr. Refaeli and his colleagues at National Jewish and the University of California , San Francisco developed a series of transgenic mice to evaluate the role of the B-cell receptor in B-cell lymphomas. They found that the presence of a functional B-cell receptor increased the development of tumors in mice with a translocated MYC oncogene.

In a series of experiments, Dr. Refaeli demonstrated that the B-cell receptor cooperated with MYC in the development of tumors both in the presence of an antigen and when no antigen was present. When no antigen was present, the mice developed a lymphoma similar to human B-cell lymphocytic leukemia.

When there was an antigen to bind to the B-cell receptor, the mice developed a lymphoma that closely resembled Burkitt’s lymphoma, even to the surprising development of primary tumors in one side of the jaw. The researchers actually used an autoantigen, a molecule produced by the mouse itself, in a situation resembling autoimmune disease. Autoimmune disease increases by 50 to 200 times the chance that a person will develop B-cell lymphoma.

In experiments that both confirmed the crucial role of the B-cell receptor and pointed to potential therapies, Dr. Refaeli and his colleagues also were able to prevent and eliminate tumors by treating the mice with immunosuppressants, which block signals from the B-cell receptor. Several trials of various immunosuppressants and another inhibitor of B-cell receptor signaling have recently begun.

“Research into B-cell lymphomas has been hampered by the lack of a good mouse model,” said Dr. Refaeli. “The mouse we created gives us a very good, predictive model of B-cell lymphomas, which can be used to explore not only these and related cancers, but also autoimmune disease and basic immunology.”

Adam Dormuth | EurekAlert!
Further information:
http://www.njc.org

Further reports about: Antigen B cells B-cell Myc Refaeli lymphoma

More articles from Life Sciences:

nachricht Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)

nachricht CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>