Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crucial Factors in Lymphoma Development and Survival Discovered

24.06.2008
Experiments with new mouse model suggest therapeutic targets

Researchers at National Jewish Medical and Research Center have discovered an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer. The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas.

The research team, led by Yosef Refaeli, PhD, Assistant Professor of Pediatrics at National Jewish Medical and Research Center , also showed that disruption of signals from the B-cell receptor can inhibit growth of the tumors. The research is being published in the June 24 issue of the journal, PLos Biology.

“Non-hodgkins lymphomas, about 90 percent of which are B-cell lymphomas, have become 85 percent more prevalent in the past 20 years, the only major form of cancer to experience such growth” said Dr. Refaeli. “Our findings have pointed to the B-cell receptor and its signaling pathways as very promising therapeutic targets for B-cell lymphomas.”

... more about:
»Antigen »B cells »B-cell »Myc »Refaeli »lymphoma

Non-Hodgkins lymphoma is a cancer of lymphocytes, immune system cells known as T cells and B cells. About 66,000 new cases of non-Hodgkins lymphoma are diagnosed each year in the United States , and about 19,000 people die of it.

It has long been known that the oncogene MYC plays a crucial role in the development of lymphomas. One unanswered question, however, is whether the B-cell receptor on the surface of B cells, may also play an important role.

When the B-cell receptor binds to molecules on foreign invaders, known as antigens, it sends a signal that causes the B cells to proliferate and produce antibodies. The antibodies bind to the foreign molecules and mark the invaders for destruction. Even if it doesn’t bind to an antigen, the B-cell receptor promotes the survival of B cells through an unknown intracellular signal.

Dr. Refaeli and his colleagues at National Jewish and the University of California , San Francisco developed a series of transgenic mice to evaluate the role of the B-cell receptor in B-cell lymphomas. They found that the presence of a functional B-cell receptor increased the development of tumors in mice with a translocated MYC oncogene.

In a series of experiments, Dr. Refaeli demonstrated that the B-cell receptor cooperated with MYC in the development of tumors both in the presence of an antigen and when no antigen was present. When no antigen was present, the mice developed a lymphoma similar to human B-cell lymphocytic leukemia.

When there was an antigen to bind to the B-cell receptor, the mice developed a lymphoma that closely resembled Burkitt’s lymphoma, even to the surprising development of primary tumors in one side of the jaw. The researchers actually used an autoantigen, a molecule produced by the mouse itself, in a situation resembling autoimmune disease. Autoimmune disease increases by 50 to 200 times the chance that a person will develop B-cell lymphoma.

In experiments that both confirmed the crucial role of the B-cell receptor and pointed to potential therapies, Dr. Refaeli and his colleagues also were able to prevent and eliminate tumors by treating the mice with immunosuppressants, which block signals from the B-cell receptor. Several trials of various immunosuppressants and another inhibitor of B-cell receptor signaling have recently begun.

“Research into B-cell lymphomas has been hampered by the lack of a good mouse model,” said Dr. Refaeli. “The mouse we created gives us a very good, predictive model of B-cell lymphomas, which can be used to explore not only these and related cancers, but also autoimmune disease and basic immunology.”

Adam Dormuth | EurekAlert!
Further information:
http://www.njc.org

Further reports about: Antigen B cells B-cell Myc Refaeli lymphoma

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>