"It has long been assumed that measles virus infects the airway epithelium before infecting immune cells," says Roberto Cattaneo, Ph.D., Mayo Clinic virologist and senior author of the study. "But we've shown that replication in the airways is not required, and that a virus replicating only in immune cells causes measles in monkeys."
The research team generated a measles virus that cannot enter the airway epithelium and showed that it spread in lymphocytes, cells of the immune system, and remained virulent. Researchers also showed, as they predicted in a new model of infection, that the virus could not cross the respiratory epithelium on its way out of the lungs and was not shed from infected monkeys.
Significance of the Research
From a treatment standpoint, the findings help physician-researchers better understand how measles virus, which can be reprogrammed to eliminate cancer cells, spreads in its host. The research may help improve efficacy and safety of cancer therapy, and lead to a better understanding of how viruses similar to measles function. A result could be more effective vaccines for other diseases.
From a strictly scientific perspective, the study challenges a widely held assumption about this common contagion. In the introduction to their article, the researchers cite two recent medical texts on the measles virus that say it infects the upper respiratory epithelium before spreading to the rest of the body. In light of their findings, the investigators say those statements will have to be revised.
The team tested their hypothesis by developing a form of the measles virus that could not enter epithelia because it was made "blind" to the epithelial cell receptor, but could enter lymphatic cells through another receptor. The virus was tested on rhesus monkeys, inoculated via the nasal tract. They developed a rash and lost weight (both symptoms of measles in the species), but follow-up tests showed that the virus did not enter through the airway epithelium, though the lymph system was infected.
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences