Given the appearance of benzene derivatives in biomedical research and materials science, the boron-nitrogen substituted analogues could potentially play a pivotal role in these areas.
In the Journal of the American Chemical Society, Liu's team reports that, by using a structural approach, benzene surrogates known as 1,2-dihydro-1,2-azaborines possess electron-delocalized structures consistent with aromaticity -- a core concept in chemistry. The paper already has drawn praise by other researchers in a story in this week's Chemical & Engineering News.
"The bottom line is that we have synthesized reference compounds designed to be non-aromatic, and through the comparisons of the aromatic molecule with the reference compounds, we were able to unambiguously say that this compound is really electron delocalized in a way consistent with aromaticity," Liu said. "With the results of other research in this field, our findings present a very strong case that 1,2-dihydro-1,2-azaborines are indeed aromatic."
Liu is among molecule-making chemists who are interested in manipulating heterocycles -- ring-like structures that contain various elements in addition to carbon. Aromatic heterocycles play a big role in pharmaceuticals, Liu said, noting that eight of the top ten selling molecules on the market today contain aromatic compounds.
For biomedical purposes, Liu said, boron-containing molecules disguised with other components readily accepted by living tissues could conceivably be used as markers to track the location of the drug. Eventually, he said, targeted drug therapies might deliver very specific tumor-destroying action that leaves healthy cells untouched.
"Our objective is really to first develop the synthetic chemistry of these boron-nitrogen heterocycles, make it accessible to other chemists to study, and ultimately go into applied research to create opportunities in cancer therapies and materials sciences," Liu said. "I believe that we have made substantial progress for expanding the scope of accessible molecules such as this. The methods we have developed here at the University of Oregon are beginning to be quite useful."
Co-authors on the paper were lead author Eric R. Abbey, a doctoral student, and Lev N. Zakharov, director of the X-Ray Diffraction Lab in the UO's Center for Advanced Materials Characterization in Oregon (CAMCOR). The research was funded in part by the National Science Foundation.About the University of Oregon
Source: Shih-Yuan Liu, assistant professor of chemistry, College of Arts and Sciences, 541-346-5573; firstname.lastname@example.org
Links: Shih-Yuan Liu's faculty page: http://www.uoregon.edu/~chem/liu.html; CAMCOR Web site: http://materialscience.uoregon.edu/Outreach/CAMCOR/About.html; College of Arts and Sciences: http://cas.uoregon.edu/
Jim Barlow | newswise
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine