Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New design may lead to custom-tailored drugs with no side effects

18.06.2008
In the May issue of the British journal Drug Discovery Today, Sten Ohlson, professor of biotechnology at Kalmar University in Sweden, argues in a debate article how his thoughts and research results surrounding weak or transient interactions between biochemical molecules could revolutionize tomorrow's drugs.

Sten Ohlson has extensive experience of research into so-called transient biomolecular binding. Such binding is short-lived­-the biomolecules touch each other for a brief moment only. Many of the processes in the human body­-in a cell, for instance­-occur with the aid of transient binding.

The discovery and understanding of how important binding can be is now paving the way for an entirely new type of drug that will be both more effective and multicompetent and moreover will be less likely than today's drugs to lead to the development of tolerance in patients.

It is above all in three areas that Professor Sten Ohlson envisions major potential for the new technology: cardiovascular diseases, pain, and neurological disorders.

... more about:
»Ohlson »Sten »binding

Some multicompetent drugs based on transient interaction are already in use today. One of them is regular aspirin, where acetyl salicylic acid transiently binds to many target structures and thereby works both as a pain reliever and an inflammation alleviator.

At present Sten Ohlson is collaborating with drug companies in the search for substances that can prevent blood clots in connection with heart attacks and stroke.

Sten Ohlson's research on the importance of transient molecular bindings in biological systems is revolutionary, but he maintains that its application is predicated upon other researchers' abandoning old, traditional approaches.

"The greatest obstacle at present, I believe, is getting scientists to begin to think transiently. This is an entirely new way of conceptualizing and understanding the fundamental functions of diseases that affect us and how we can cure them," says Sten Ohlson.

Karin Ekebjär | alfa
Further information:
http://www.hik.se

Further reports about: Ohlson Sten binding

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>