Sten Ohlson has extensive experience of research into so-called transient biomolecular binding. Such binding is short-lived-the biomolecules touch each other for a brief moment only. Many of the processes in the human body-in a cell, for instance-occur with the aid of transient binding.
The discovery and understanding of how important binding can be is now paving the way for an entirely new type of drug that will be both more effective and multicompetent and moreover will be less likely than today's drugs to lead to the development of tolerance in patients.
It is above all in three areas that Professor Sten Ohlson envisions major potential for the new technology: cardiovascular diseases, pain, and neurological disorders.
Some multicompetent drugs based on transient interaction are already in use today. One of them is regular aspirin, where acetyl salicylic acid transiently binds to many target structures and thereby works both as a pain reliever and an inflammation alleviator.
At present Sten Ohlson is collaborating with drug companies in the search for substances that can prevent blood clots in connection with heart attacks and stroke.
Sten Ohlson's research on the importance of transient molecular bindings in biological systems is revolutionary, but he maintains that its application is predicated upon other researchers' abandoning old, traditional approaches.
"The greatest obstacle at present, I believe, is getting scientists to begin to think transiently. This is an entirely new way of conceptualizing and understanding the fundamental functions of diseases that affect us and how we can cure them," says Sten Ohlson.
Karin Ekebjär | alfa
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Nanoparticles help with malaria diagnosis – new rapid test in development
21.11.2017 | Fraunhofer-Institut für Silicatforschung ISC
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
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The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
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Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
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