"We tested for an association between genetic variants across the human genome and fasting glucose and insulin," says Richard M. Watanabe, Ph.D., associate professor of preventive medicine and physiology & biophysics at the Keck School of Medicine of USC and lead author of the paper.
"We found a novel association between fasting glucose and the melatonin receptor 1B (MTNR1B). It's novel because this is the first time a genetic variant has been associated with both glucose and increased risk of diabetes."
The study examined genetic information from 6,543 people participating in three independent genome-wide association studies for fasting glucose and insulin. The studies included Finland-United States Investigation of Non-insulin-dependent Diabetes Mellitus (FUSION) study and the SardiNIA study of aging and the Diabetes Genetics Initiative.
"The MTNR1B finding is interesting because melatonin is involved with regulating circadian rhythms, like sleep cycles, and people with sleep disorders, like sleep apnea, tend to develop obesity and insulin resistance, which are risk factors for type 2 diabetes," continues Watanabe. "More studies will be needed to understand how MTNR1B is involved in regulating glucose and associated risk for diabetes."
Jennifer Chan | EurekAlert!
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
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COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
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