A lifespan-extending calorie-restricted diet reversed some of the aging effects – but, unlike the widespread changes observed in somatic organs, it had an impact only in a small number of gonad-specific genes.
As well as tackling one of the key questions of ageing – by exploring if reproductive organs age in the same way as other body organs – this research is important in the light of the trend for some women in developed countries to put off childbearing until later in life.
A research team led by Minoru Ko, MD, PhD, from the National Institute on Aging, Baltimore, USA used whole-genome DNA microarrays to study the effects of age, sex and diet on the global gene expression in mouse ovaries and testes. They found that reproductive organs age in a different way to other body tissues and, furthermore, that ovaries age in a different way from testes.
Age-related changes in gene expression occurred in gonads – as they are known to in other body tissues – but these changes tended to be in different classes of genes. Only two of the six categories of genes previously associated with aging in muscle, kidney and brain were associated with aging in the ovary; none were associated with aging in the testis. The changes seen in ovaries could be influenced by changes in the tissue composition of ovaries as females age and ovulation ceases.
The researchers also found that calorie restriction in females reduced the expression of genes involved in metabolism and follicle growth, which seems to be consistent with a popular view that the calorie restriction causes a shift in energy use away from reproduction towards general body maintenance and repair. However, male mice on the same diet did not appear to sacrifice reproductive function, suggesting an evolutionary difference between males and females when coping with a food shortage.
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Earth Sciences
18.01.2018 | Business and Finance
18.01.2018 | Medical Engineering