Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain cells help neighboring nerves regenerate

29.05.2008
Article appearing in the May 30 Journal of Biological Chemistry

Researchers have uncovered a completely unexpected way that the brain repairs nerve damage, wherein cells known as astrocytes deliver a protective protein to nearby neurons.

Astrocytes are a type of support cell in the brain that serve many functions; one of their roles is to chew up damaged nerves during brain injury and then form scar tissue in the damaged area.

Roger Chung and colleagues have now found that astrocytes have another trick up their sleeve. During injury, astrocytes overproduce a protein called metallothionein (MT) and secrete it to surrounding nerves; MT is a scavenging protein that grabs free radicals and metal ions and prevents them from damaging a cell, and thus is a potent protecting agent.

... more about:
»Nerve »Protein »astrocytes »repair

While the ability of astrocytes to produce MT has been known for decades, the general view was that the MT stayed within astrocytes to protect them while they help repair damaged areas. However, Chung and colleagues demonstrated that MT was present in the external fluid of damaged rat brain. Furthermore, with the aid of a fluorescent MT protein, they observed that MT made in astrocytes could be transported outside the cell and then subsequently taken up by nearby nerves, and that the level of MT uptake correlated with how well the nerves repaired damage.

While the exact physiological role that MT plays in promoting better repair remains to be identified, this unexpected role for this protein should open up new avenues in treating brain injuries in the future.

Nick Zagorski | EurekAlert!
Further information:
http://www.asbmb.org
http://www.jbc.org/cgi/content/full/283/22/15349

Further reports about: Nerve Protein astrocytes repair

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>