”By looking at biological events we have found differences that in future could be used as markers to make a more secure prognosis for women with ovarian cancer”, says biologist Karolina Partheen, who has written the thesis.
Ovarian cancer is an unusual disease in Sweden. But despite few persons being afflicted by it, it is the fifth most common cause of women dying of cancer in our country. When tumors are discovered there are a number of factors that influence what type of treatment the patient will undergo. Patients with a similar prognosis can have completely different experiences. This is a big problem within cancer care today, in the treatment of ovarian cancer and in the treatment of other forms of cancer too. The majority of patients undergo insufficient treatment resulting in serious side effects, which represents a big cost for both patients and healthcare.
”In the long run only half of all patients with ovarian cancer respond to the medication they are subjected to. What causes the difference in the way patients respond to antineoplastic agents is not completely clear today, but an underlying cause could be that the tumors have different biological characteristics”, says Karolina Partheen.
Cancer is caused by something changing in our gene pool, our genes, which make the body’s own cells start dividing uncontrollably. Genes are copied to mRNA that later function as templates from which proteins can be built in a cell. Certain proteins speed up the cell’s division time, while others put the brakes on it. So if there is too much or too little of some protein, or if it becomes wrongly constructed, this can lead to cancer.
In her thesis, Karolina Partheen has measured gene copies and how much mRNA or protein has built in different tumors that have the same prognosis. This is done in order to then compare whether there are any differences between tumors from patients who survive or die from the disease.
”One of the most interesting discoveries in the thesis was a profile that seems to be able to distinguish a particular group of patients where everyone survives. In future, if these patients can be detected before treatment with antineoplastic agents, they would be able to get an alternative treatment that results in fewer side effects. Patients that do not correspond to our profile can receive standard treatment with some further medication from the start and tighter follow-ups. In this way the treatment becomes more effective, and side effects are minimised, as well as costs reduced for any over-treatment of patients”, says Karolina Partheen.
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy