Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC scientists discover how some bacteria survive antibiotics

05.05.2008
Researchers at the University of Illinois at Chicago have discovered how some bacteria can survive antibiotic treatment by turning on resistance mechanisms when exposed to the drugs. The findings, published in the April 24 issue of the journal Molecular Cell, could lead to more effective antibiotics to treat a variety of infections.

"When patients are treated with antibiotics some pathogenic microbes can turn on the genes that protect them from the action of the drug," said Alexander Mankin, professor and associate director of the University of Illinois at Chicago's Center for Pharmaceutical Biotechnology and lead investigator of the study. "We studied how bacteria can feel the presence of erythromycin and activate production of the resistance genes."

Erythromycin and newer macrolide antibiotics azithromycin and clarithromycin are often used to treat respiratory tract infections, as well as outbreaks of syphilis, acne and gonorrhea. The drugs can be used by patients allergic to penicillin.

Macrolide antibiotics act upon the ribosomes, the protein-synthesizing factories of the cell. A newly-made protein exits the ribosome through a tunnel that spans the ribosome body. Antibiotics can ward off an infection by attaching to the ribosome and preventing proteins the bacterium needs from moving through the tunnel.

... more about:
»Infection »antibiotic »bacteria »genes »ribosome

Some bacteria have learned how to sense the presence of the antibiotic in the ribosomal tunnel, and in response, switch on genes that make them resistant to the drug, Mankin said. The phenomenon of inducible antibiotic expression was known decades ago, but the molecular mechanism was unknown.

Mankin and his team of researchers -- Nora Vazquez-Laslop, assistant professor in the Center for Pharmaceutical Biotechnology, and undergraduate student Celine Thum -- used new biochemical and genetic techniques to work out the details of its operation.

"Combining biochemical data with the knowledge of the structure of the ribosome tunnel, we were able to identify some of the key molecular players involved in the induction mechanism," said Vazquez-Laslop.

"We only researched response to erythromycin-like drugs because the majority of the genetics were already known," she said. "There may be other antibiotics and resistance genes in pathogenic bacteria regulated by this same mechanism. This is just the beginning."

Sam Hostettler | EurekAlert!
Further information:
http://www.uic.edu

Further reports about: Infection antibiotic bacteria genes ribosome

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>