Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Menstrual blood -- a valuable source of multipotential stem cells?

Researchers seeking new and more abundant sources of stem cells for use in regenerative medicine have identified a potentially unlimited, noncontroversial, easily collectable, and inexpensive source – menstrual blood.

Stromal stem cells - cells that are present in connective tissues - have recently been identified in endometrial tissues of the uterus. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capabilities are present and collectable. While collecting menstrual blood stromal cells (MenSCs) directly from tissue would be invasive, retrieving them during the menstrual cycle would not be.

“Stromal stem cells derived from menstrual blood exhibit stem cell properties, such as the capacity for self-renewal and multipotency,” said Amit N. Patel, MD, MS, Director of Cardiac Cell Therapy at the University of Pittsburgh’s McGowan Institute of Regenerative Medicine. “Uterine stromal cells have similar multipotent markers found in bone marrow stem cells and originate in part from bone marrow.”

Published in the most recent issue of Cell Transplantation (Volume 17, issue 3), the study examined to what degree MenSCs demonstrated an ability to differentiate into a variety of cell lineages.

... more about:
»MenSCs »Patel »Source »Stem »menstrual »regenerative »stem cells

Tests showed that MenSCs could differentiate into adipogenic, chondrogenic, osteogenic, ectodermal, mesodermal, cardiogenic, and neural cell lineages. According to Patel, the sample MenSCs expanded rapidly and maintained greater than 50 percent of their telomerase activity when compared to human embryonic stem cells and better than bone marrow-derived stem cells. “Studies have demonstrated that MenSCs are easily expandable to clinical relevance and express multipotent markers at both the molecular and cellular level,” concluded Patel.

Researchers emphasized the importance of the abundance and plasticity of MenSCs. Based on the results of their studies, they noted the potential for MenSCs in regenerative transplantation therapies for many different organs and tissues. “The need for regenerative therapies using cells with the ability to engraft and differentiate is vast,” said Patel.

“The ideal cell would also have the ability to be used in an allogenic manner from donors for optimal immunogenic compatibility. Due to their ease of collection and isolation, MenSCs would be a great source of multipotent cells if they exhibit this property along with their ability to differentiate,” concluded Julie G. Allickson, Ph.D., Vice President of Laboratory Operations and Research & Development, Cryo-Cell International, Inc., the study-partner company that identified, extracted, and initially analyzed the cells. “The preliminary results are extremely encouraging and support the importance of further study of these cells in several different areas including heart disease, diabetes and neurodegenerative disease.”

Dwaine Emerich, Ph.D., a section editor for Cell Transplantation, believes that “These studies are a significant step forward in the development of transplantable stem cells for human diseases because they address major issues including routine and safe cell harvesting of renewable cells that maintain their differentiation capacity and can be scaled for widespread clinical use.”

Amit Patel | EurekAlert!
Further information:

Further reports about: MenSCs Patel Source Stem menstrual regenerative stem cells

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>