Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bloodless Worm Sheds Light on Human Blood, Iron Deficiency

18.04.2008
Using a lowly bloodless worm, University of Maryland researchers have discovered an important clue to how iron carried in human blood is absorbed and transported into the body. The finding could lead to developing new ways to reduce iron deficiency, the world's number one nutritional disorder.

With C. elegans , a common microscopic worm that lives in dirt, Iqbal Hamza, assistant professor of animal and avian sciences, and his team identified previously unknown proteins that are key to transporting heme, the molecule that creates hemoglobin in blood and carries iron. It is a critical step in understanding how our bodies process iron. Their findings are published in the April 16 issue of Nature online.

"The structure of hemoglobin has been crystallized over and over," says Hamza, "but no one knows how the heme gets into the globin, or how humans absorb iron, which is mostly in the form of heme.

"To understand the underlying issues of nutritional and genetic causes of iron deficiency, we are looking at the molecules and mechanisms involved in heme absorption. Once you understand transport of heme, you can more effectively deliver it to better absorb iron in the human intestine."

... more about:
»Hamza »Iron »blood »deficiency »elegans »heme

Heme and Blood

Heme is a critical molecule for health in all eukaryotes, organisms whose cells are organized into complex structures enclosed in membranes. Species of eukaryotes range from humans to baker's yeast. Heme makes blood red and binds to oxygen and other gases we need to survive.

Heme is created in the mitochondria, then moves through pathways that connect other cells, where it is synthesized to form blood. Heme on its own, however, is toxic. "We wanted to find out how heme gets carried between and within cells," said Hamza.

A Bloodless Worm

Eight steps are required to generate heme, making it a difficult process to control in the study of heme transport pathways, as Hamza learned when he first studied the question in bacteria and mice.

So Hamza did the non-intuitive thing. He chose a test subject that doesn't make heme, but needs it to survive, that doesn't even have blood, but shares a number of genes with humans - the C. elegans roundworm, a simple nematode.

"We tried to understand how blood is formed in an animal that doesn't have blood, that doesn't turn red, but has globin," Hamza said.

C. elegans gets heme by eating bacteria in the soil where it lives. "C. elegans consumes heme and transports it into the intestine. So now you have a master valve to control how much heme the animal sees and digests via its food," Hamza explains.

C. elegans has several other benefits for studying heme transport. Hamza's team could control the amount of heme the worms were eating. With only one valve controlling the heme transport, the scientists knew exactly where heme was entering the worm's intestine, where, as in humans, it is absorbed.

And C. elegans is transparent, so that under the microscope researchers could see the movement of the heme ingested by the worm.

Genes and Iron Deficiency

The study revealed several findings that could lead to new treatment for iron deficiency. One was the discovery that genes are involved in heme transport. Hamza's group found that HRG-1 genes, which are common to humans and C. elegans , were important regulators of heme transport in the worm.

To test their findings in an animal that makes blood, Hamza's team removed the HRG-1 gene in zebrafish. The fish developed bone and brain defects, much like birth defects. The gene removal also resulted in a severe form of anemia usually caused by iron deficiencies.

When they substituted the zebrafish gene with the worm HRG-1 gene, the mutant fish returned to normal, indicating that the fish and worm genes are interchangeable, irrespective of the animal's ability to make blood.

They also found that too little or too much heme can kill C. elegans , a result that could help researchers find ways to treat people who suffer from iron deficiency caused by parasitic worms.

"More than two billion people are infected with parasites," says Hamza. "Hookworms eat a huge amount of hemoglobin and heme in their hosts. If we can simultaneously understand heme transport pathways in humans and worms, we can exploit heme transport genes to deliver drugs disguised as heme to selectively kill parasites but not harm the host."

Other researchers on the study were Abbhirami Rajagopal, Anita U. Rao, Caitlin Hall, Suji Uhm, University of Maryland ; Julio Amigo, Barry H. Paw, Brigham and Women's Hospital, Boston ; Meng Tian, Mark D. Fleming, Children's Hospital, Boston ; Sanjeev K. Upadhyay, M.K. Mathew, Tata Institute of Fundamental Research, Bangalore , India ; Michael Krause, National Institute of Diabetes and Digestive and Kidney Diseases, NIH.

The research was funded by grants from the National Institutes of Health, the March of Dimes Birth Defects Foundation, Council for Scientific and Industrial Research and Kanwal Rekhi Fellowships, and the Howard Hughes Medical Institute Undergraduate Science Education Program.

Ellen Ternes | EurekAlert!
Further information:
http://www.umd.edu

Further reports about: Hamza Iron blood deficiency elegans heme

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>