In Germany, about 8 million people are affected. These numbers could even be an underestimation as a relatively high number of undiagnosed diabetics remains. The newly-published meta analysis 1) on the genetics of type 2 diabetes casts new light on the origin of this disease.
With participation of scientists of the Helmholtz Zentrum Muenchen, the international study confirms findings that the disease is at least partly based on a misregulation of insulin producing cells.
The newly published meta analysis, in which 90 scientists from more than 40 centers were involved, evaluated data of 15 European and American studies. It was possible to identify six new genes that play a role in the development of type 2 diabetes. This brings the number of genes associated with the disease to 16.
Type 2 diabetes is characterized by perpetually raised blood sugar levels, which, untreated, can lead to damage of blood vessels, the kidneys and other important organs. Life style factors, such as overweight and lack of exercise, play an important role for disease aetiology. Nevertheless, a strong genetic component also underlies type 2 diabetes, which has been studied for some years, with the help of linkage and association studies.
The knowledge now gained allows new insights into the mechanisms responsible for the control of blood sugar levels in the blood.
The meta analysis comprises altogether studies with more than 70,000 participants. As a German contribution, data from about 2,700 participants of the KORA study were included. The involved scientists from Germany were Harald Grallert, Dr. Christa Meisinger and Dr. Thomas Illig, from the Helmholtz Zentrum Muenchen, in close collaboration with Dr. Christian Herder and Dr. Wolfgang Rathmann, from the German Diabetes Center in Duesseldorf.
The head of the KORA study (Cooperative Health Research in the Region of Augsburg) is the director of the Institute of Epidemiology in the Helmholtz Zentrum Muenchen, Prof. Dr. Dr. H.-Erich Wichmann. The coordinator of the analysis was Dr. Eleftheria Zeggini, University of Oxford, under the direction of Prof. Mark McCarthy.
Michael van den Heuvel | alfa
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy