Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aldosterone – the key to curing high blood pressure?

10.04.2008
Understanding the role of the hormone aldosterone could provide hope of new therapeutic treatments to millions of people who suffer from high blood pressure.

That’s the conclusion of a large body of research being presented today at the annual Society for Endocrinology BES meeting in Harrogate. Aldosterone plays a key role in regulating blood pressure and can affect how susceptible you are to developing hypertension later in life.

Researchers at the Medical Research Council Blood Pressure Unit at the University of Glasgow, led by Prof John Connell, have studied the way in which aldosterone affects blood pressure regulation. Aldosterone is a hormone that is produced by the adrenal glands. It acts on the kidneys to make sure that salt levels in the blood are kept at a safe level. However, it also has important actions to alter heart and blood vessel function. Too much aldosterone increases the risk of stroke and heart failure.

The group found that in older people, higher levels of aldosterone in the bloodstream are associated with high blood pressure, while in young adults, high aldosterone levels indicate you are more likely to subsequently develop hypertension later in life. Individual aldosterone levels are determined by a number of factors. People born with a low birth weight tend to have higher aldosterone levels when they are older. Another important influence is genetics - some people have variants of a gene that controls aldosterone that works more efficiently than others. This means that throughout life, certain individuals will have higher aldosterone levels and are more prone to developing high blood pressure. This also suggests that in the future, we may be able to predict from an early age which individuals are more likely to develop hypertension. Lifestyle modification and new drug treatments might then be targeted specifically at this group of people.

... more about:
»Heart »aldosterone »hypertension »pressure

Approximately 1 in 4 people in the UK have hypertension. The higher your blood pressure, the greater your risk of suffering from a heart attack or a stroke. Evidence suggests that aldosterone may be a causal factor in 10% of patients with high blood pressure(1).

Researcher Prof John Connell said:
“Aldosterone is a key cardiovascular hormone. The higher the level of aldosterone in your blood, the more likely it is that you will suffer from high blood pressure, which will increase your risk of suffering a heart attack or a stroke.

Through our research, we have discovered some of the factors that predispose you to having higher aldosterone levels. We now need to build up a better understanding of how production of aldosterone throughout life is controlled. This could help us to discover how to prevent blood pressure rising with age and also allow us to target new drug treatments for high blood pressure.”

Jennie Evans | alfa
Further information:
http://www.endocrinology.org
http://www.endocrinology.org/meetings/2008/BES2008/prog/prog.aspx

Further reports about: Heart aldosterone hypertension pressure

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>