A newly established national biomedical center at Cornell University is reporting its first major advance: a new way of measuring, or "visualizing," proteins. The new technique will hasten the transformation of the human genome project’s blueprints of life into a comprehensive view of the biochemical and physiological circuitry that interconnect to form entire organisms.
The technique, which determines the structure of a protein by measuring the distances between atoms in the molecule at greater separations than previously possible, is an important development, says Jack Freed, professor of chemistry and chemical biology at Cornell, who is director of the National Biomedical Center for Advanced ESR Technology (ACERT), established at Cornell last year by the National Institutes of Health. "This is in the spirit of seeing the whole forest of the protein, whereas before we have been seeing the trees one after another," says Freed.
Freed and his collaborators, Hassane Mchaourab, professor of molecular physiology and biophysics at the Vanderbilt University School of Medicine, and Peter Borbat, associate director of ACERT, report on the new method for protein structure determination in JACS , the Journal of the American Chemical Society (May 22, 2002).
David Brand | EurekAlert!
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