Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stem Cells from Hair Follicles May Help "Grow" New Blood Vessels

01.04.2008
For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients' heads, according to new research published earlier this month by University at Buffalo engineers.

"Engineering blood vessels for bypass surgery, promoting the formation of new blood vessels or regenerating new skin tissue using stem cells obtained from the most accessible source -- hair follicles -- is a real possibility," said Stelios T. Andreadis, Ph.D., co-author of the paper in Cardiovascular Research and associate professor in the Department of Chemical and Biological Engineering in the UB School of Engineering and Applied Sciences.

Researchers from other institutions previously had shown that hair follicles contain stem cells.

In the current paper, the UB researchers demonstrate that stem cells isolated from sheep hair follicles contain the smooth muscle cells that grow new vasculature. The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells.

"We have demonstrated that engineered blood vessels prepared with smooth muscle progenitor cells from hair follicles are capable of dilating and constricting, critical properties that make them ideal for engineering cardiovascular tissue regeneration," said Andreadis.

In addition to growing new skin for burn victims, cells from hair follicles could potentially be used to engineer vascular grafts and possibly regenerate cardiac tissues for patients with heart problems.

Since smooth muscle cells comprise the muscle of numerous tissues and organs, including the bladder, abdominal cavity and gastrointestinal and respiratory tracts, this new, accessible source of cells may make possible future treatments that allow for the regeneration of these damaged organs as well.

Andreadis and his colleagues previously engineered functional and implantable blood vessels with smooth muscle and endothelial cells originating from bone-marrow mesenchymal stem cells.

A key advantage of mesenchymal cells is that they typically do not trigger an immune reaction when transplanted, he said.

"Preliminary experiments in our laboratory suggest an exciting possibility -- that stem cells from hair follicles may be similar to bone-marrow mesenchymal cells," Andreadis said.

"The best case scenario is that from this one very accessible and highly proliferative source of stem cells, we will be able to obtain multiple different cell types that can be used for a broad range of applications in regenerative medicine," he said.

Co-authors on the paper are Jin Yu Liu, Ph.D., research assistant professor, and Hao Fan Peng, a doctoral candidate, both in the UB Department of Chemical and Biological Engineering.

The work was funded by the John R. Oishei Foundation of Buffalo. Previous work by Andreadis has been funded by UB's Integrative Research and Creative Activities Fund in the UB Office of the Vice President for Research.

The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system that is its largest and most comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.

Ellen Goldbaum | EurekAlert!
Further information:
http://www.buffalo.edu

Further reports about: Andreadis Muscle Source blood vessel follicles stem cells

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>