Harvard University researchers have discovered a new type of retinal cell that plays an exclusive and unusual role in mice: detecting upward motion. The cells reflect their function in the physical arrangement of their dendrites, branch-like structures on neuronal cells that form a communicative network with other dendrites and neurons in the brain.
The work, led by neuroscientists Joshua R. Sanes and Markus Meister, is described this week in the journal Nature.
"The structure of these cells resembles the photos you see in the aftermath of a hurricane, where all the trees have fallen down in the same direction," says Meister, the Jeff C. Tarr Professor of Molecular and Cellular Biology in Harvard's Faculty of Arts and Sciences. "When you look at these neurons in the microscope, they all point the same way. There’s no other cell type in the retina that has that degree of directionality."
The cells, like other retinal neurons, are composed of a round cell body surrounded by a tangle of dendrites. Most retinal neurons distribute their dendrites evenly around the cell body, but the upward motion-detecting cells arrange almost 90 percent of their dendrite tangle exclusively on one side of the cell body.
"This lopsided arrangement literally directs the cell's function, orienting the dendrites downward like roots of great trees," says Sanes, professor of molecular and cellular biology and Paul J. Finnegan Family Director of Harvard's Center for Brain Science. "Because the eye's lens acts as a camera, reversing incoming light rays as they strike the retinal tissue, an object moving up will result in a downward-moving image at the back of the eye -- the exact orientation of the cells' dendrites."
The research builds on efforts by Meister to understand neural processing in the retina, as well as work in Sanes's laboratory to identify and mark neurons in the retina using molecular tags. Recently, they tracked down a family of molecules expressed exclusively by small subsets of retinal cells in mice. One in particular, called JAM-B, was present in cells that had a peculiar distribution and orientation.
According to Sanes, developmental neurologists have long tried to identify different types of neural cells based on their function and anatomy -- how they appeared on the outside.
"But it's a huge limitation because it's essentially a qualitative assessment," he says. "We really need some way to reliably identify and track these cells if we ever hope to study their development. So the emergence of cell-specific molecular markers is a very big deal, because it will do just that. Already we've seen that it helps us identify new kinds of cells we didn't know existed before. Once we have a promising molecule, we can track down the cells that it corresponds to."
"The other important result," continues Sanes, "is that we're actually mimicking how the brain itself identifies its cells. The brain has to be able to reliably recognize and tell apart different kinds of cells, and that's going to happen on a molecular basis. In fact, it’s possible that some of the molecules we've identified are, in fact, the same molecules the brain uses to distinguish cell types."
By identifying molecules that are solely expressed by specific types of neurons, scientists hope to gain insights into how nerve cells form synapses, or connections, with other nerve cells -- in short, how the brain controls its development on a molecular basis.
For the moment, however, researchers are busy puzzling over the results of the JAM-B mouse retinal cells.
"Why in the world would mice need to develop cells to detect upward motion"" Sanes wonders. "It's a great mystery."
Steve Bradt | EurekAlert!
Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy