In an article in the journal Proceedings of the National Academy of Science (PNAS) Uppsala researchers are now presenting results of experiments that contradict the theory.
Proteins govern nearly all chemical processes in the body's cells. A fundamental property of proteins is their ability to transfer signals – both within and between proteins. It is known, for example, that such signal transfer is vital to haemoglobin, which transports oxygen in the body. In that instance the mechanism has largely been clarified.
"But in other instances very little is known about the mechanisms or whether such signal transfer even occurs," says Per Jemth, who together with his research group at Uppsala University is studying whether signal transfer also occurs in small proteins.
Nearly ten years ago great attention was attracted by an article published in Science that described a method of demonstrating signal transfer in proteins by comparing their amino acid sequence. The authors recorded a statistical method of showing how certain parts of proteins change together through evolution, i.e. if a change had taken place in one part a change simultaneously took place in another part of the protein. One thus found a network of parts that seemed to belong together, and within this network signal transfer was deemed to take place.
But the Uppsala researchers saw several things that were not right about the results in the much discussed article, and by means of experiments they can now show that no more signals occur in this network than with other parts of the protein. They instead found, completely logically, that nearby parts of the protein interact more with each other than parts that are a long way apart.
"Our results thus question whether statistical methods can demonstrate signal transfer within proteins, and emphasise the importance of precise experiments to substantiate computer-based methods in protein chemistry," says Per Jemth.
The ability to predict proteins' function down to the smallest detail on the basis of their amino acid sequence is a goal that has preoccupied many researchers ever since human DNA became known. This study emphasises that experiments are needed to improve and refine the computerised methods currently in use.
"When theory, computer simulation and experiments provide the same answers the long-term goal has been attained, but there's still a long way to go."
Anneli Waara | alfa
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Power and Electrical Engineering
25.10.2016 | Process Engineering