Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First study to investigate the effect of father’s diet on chromosomal abnormalities in sperm reveals link with folate ...

20.03.2008
... - a vitamin B

Researchers have found an association between a vitamin found in leafy green vegetables, fruit and pulses [1] and levels of chromosomal abnormalities in men’s sperm. Men who consumed high levels of folate (a water-soluble B vitamin that occurs naturally in food) and folic acid (the synthetic form of the vitamin) tended to have lower levels of abnormal sperm where a chromosome had been lost or gained (known as aneuploidy).

Writing in Europe’s leading reproductive medicine journal, Human Reproduction, today (Thursday 20 March), the authors say estimates suggest that between 1-4% of sperm in a healthy man have some type of aneuploidy, but there are large variations among individuals, the mechanisms are poorly understood and little is known about the effects of men’s diet on their sperm. [2]

In the first study of its kind to investigate the relationship between sperm aneuploidy and paternal diet, they analysed sperm samples from 89 healthy, non-smoking men and questioned them about their daily total intake (from diet and from vitamin supplements) of zinc, folate, vitamin C, vitamin E and beta-carotene.

One of the principal investigators of the study, Brenda Eskenazi, Professor of Maternal and Child Health and Epidemiology and Director of the Center for Children’s Environmental Health at the School of Public Health, University of California, Berkeley, USA, said: “We found a statistically significant association between high folate intake and lower sperm aneuploidy: there was increasing benefit with increasing intake, and men in the upper 25th percentile who had the highest intake of folate between 722-1150 micrograms, had 20-30% lower frequencies of several types of aneuploidy compared with men with a lower intake.

“However, this study cannot prove that high folate intake caused the lower sperm aneuploidy levels, only that there is an association. This is the first study of its kind and the results indicate the need for further research, especially a randomised controlled trial, on this topic.”

The researchers found no consistent associations between intakes of zinc and the other vitamins and sperm aneuploidy.

Prof Eskenazi said: “While the importance of maternal diet on reproduction, especially folate intake, is well known, the results of our study suggest the importance of studying paternal nutrition when considering male-mediated developmental consequences. In previous studies, we and others have shown that paternal micronutrient intake may contribute to successful conceptions by improving the quality of the sperm. This study is the first to suggest that paternal diet may play a role after conception in the development of healthy offspring.” [3]

The current recommended daily intake (RDA) for men aged over 19 is 400 micrograms, and the authors say that if other studies confirm their findings of the link between folate intake and aneuploidy, then a possible intervention would be to increase the RDA for men considering becoming fathers for at least three months before trying to conceive in order to reduce the risk of chromosomal abnormalities in their children.

Ms Suzanne Young, a researcher in Prof Eskenazi’s group and the study co-ordinator, said: “Increasing folate intake can be as simple as taking a vitamin supplement with at least 400 micrograms of folate or eating breakfast cereal fortified with 100% of the RDA for folic acid. In addition, green leafy vegetables, such as spinach, can have up to 100 micrograms of folate per serving.”

Disentangling the effects of folate from other micronutrients (e.g. the other vitamins) can be difficult, but the authors think they have succeeded in doing this by looking at several different nutrients in statistical analyses. Ms Young said: “The results of the different analyses were different, which gave us some confidence that we could look at the effect of these micronutrients separately. The definitive way to answer this question would be with a randomised control trial with folate supplementation.”

[1] Pulses include foods such as beans, chickpeas and lentils.
[2] The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Doi:10.1093/humrep/den036

[3] Sperm aneuploidy can have a number of consequences ranging from failure to conceive, miscarriages or children born with conditions such as Down’s syndrome, Turner’s syndrome and Klinefelter’s syndrome.

Emma Mason | alfa
Further information:
http://www.oxfordjournals.org/eshre

Further reports about: Vitamin abnormalities aneuploidy chromosomal folate intake micronutrient paternal sperm

More articles from Life Sciences:

nachricht Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>