At the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, researchers have now succeeded in reconstructing the first active transposon of the Harbinger transposon superfamily.
In the laboratory, the artificial transposon developed by Dr. Ludivine Sinzelle, Dr. Zsuzsanna Izsvák, and Dr. Zoltán Ivics also shows cut-and-paste transposition in human cells and promises to serve as a useful experimental system for investigating human gene function. The findings of the MDC researchers have just been published online in the Proceedings of the National Academy of Sciences (PNAS 10.1073/pnas.0707746105)*.
Transposons comprise about half of the human genome. “They are molecular parasites, similar to fleas, only that they are in the genome of the host and not on its back,” Dr. Zoltán Ivics explained. They jump, move, and proliferate through the host, without whom they could not survive. In most cases, transposons do not fulfill any function in the human genome. “However, not all are superfluous,” Dr. Ivics went on to say. “More than 100 active genes, including some associated with the immune system, have been recognized as probably derived from transposons.”
To reconstruct an active transposon, Dr. Ivics’ team compared the DNA of various inactive Harbinger transposons, one of the largest superfamilies of transposons. Based on these results, they developed an artificial jumping gene. “We were very lucky,” Dr. Ivics said. “The very first experiment was successful.”New tool for basic research
Moreover, in the course of evolution, transposons have been responsible for the emergence of new genes. Thus, through computerized gene analysis, Dr. Ivics’ research team has discovered two new elements related to the Harbinger transposon. In a new project, Dr. Ivics aims to elucidate just what role these play in the human body.
Over the long term, scientists hope to use such transposons in gene therapy as well. With the aid of a transposon, an intact copy of a gene could be incorporated into the genome of a patient to repair a defective gene. “But until this can happen, there is still a lot to be done,” Dr. Ivics pointed out. “The new gene should not just jump in anywhere.”
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences