The study, led by Dr Jeremy Blaydes, will explore how one specific group of molecules called C-Terminal Binding Proteins (CtBPs) prevent breast cancer cell death and encourage cell growth.
Scientists have shown that in breast cancer cells, CtBPs act to prevent another molecule - p53, which is vital in causing cell death, from doing its job, so breast cancer cells continue to grow rather than die.
Dr Blaydes study will investigate exactly how CtBPs keep breast cancer cells alive and then develop a way of experimentally changing CtBPs in order to promote the death of breast cancer cells.
Dr Jeremy Blaydes, of the Cancer Sciences Division in the University's School of Medicine, said: "What we can show is that cancer cells need CtBPs to stay alive, so we've devised a laboratory technique to prevent cancer cells producing these proteins. We're trying to understand what it is about CtBPs that the cancer cells need, so we can develop therapies to prevent cancers from developing.
"Breast cancer not only affects those diagnosed with the disease, but the lives of friends and family, so it is vitally important that we are utterly committed to working towards improved diagnosis, treatment, prevention and cure."
The research is funded over three years by the Breast Cancer Campaign (BCC), a charity which specialises in funding independent breast cancer research throughout the UK. Dr Blaydes has discovered with previous BCC funding that current chemotherapies can work, in part, by inhibiting CtBP function in breast cancer cells.
Dr Blaydes adds: "By knowing more about CtBPs, we hope to improve our knowledge of how to use chemotherapy treatments more effectively."
Glenn Harris | alfa
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
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In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
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A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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