The study, led by Dr Jeremy Blaydes, will explore how one specific group of molecules called C-Terminal Binding Proteins (CtBPs) prevent breast cancer cell death and encourage cell growth.
Scientists have shown that in breast cancer cells, CtBPs act to prevent another molecule - p53, which is vital in causing cell death, from doing its job, so breast cancer cells continue to grow rather than die.
Dr Blaydes study will investigate exactly how CtBPs keep breast cancer cells alive and then develop a way of experimentally changing CtBPs in order to promote the death of breast cancer cells.
Dr Jeremy Blaydes, of the Cancer Sciences Division in the University's School of Medicine, said: "What we can show is that cancer cells need CtBPs to stay alive, so we've devised a laboratory technique to prevent cancer cells producing these proteins. We're trying to understand what it is about CtBPs that the cancer cells need, so we can develop therapies to prevent cancers from developing.
"Breast cancer not only affects those diagnosed with the disease, but the lives of friends and family, so it is vitally important that we are utterly committed to working towards improved diagnosis, treatment, prevention and cure."
The research is funded over three years by the Breast Cancer Campaign (BCC), a charity which specialises in funding independent breast cancer research throughout the UK. Dr Blaydes has discovered with previous BCC funding that current chemotherapies can work, in part, by inhibiting CtBP function in breast cancer cells.
Dr Blaydes adds: "By knowing more about CtBPs, we hope to improve our knowledge of how to use chemotherapy treatments more effectively."
Glenn Harris | alfa
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences