Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Model Identifies Targets for Eradication of Malaria and Rejects Re-Emergence Scenarios in Industrialised Countries

12.03.2008
Scientists at the Instituto Gulbenkian de Ciência (IGC), in Portugal, have shown that Malaria eradication in Africa is sustainable, and any re-emergence of malaria in industrialized nations is highly unlikely. Working with colleagues in Kenya, the IGC researchers created a mathematical model of malaria transmission throughout sub-Saharan Africa, published in this week’s PLoS ONE.

After several exposures to malaria, humans develop clinical immunity to the disease. In this state, they no longer have symptoms of malaria, but are nevertheless capable of transmitting the disease to others. In regions where malaria is endemic, many people have developed clinical immunity, and this has a large effect on how the disease spreads, that is, on its epidemiology.

Gabriela Gomes and her team at the Theoretical Epidemiology group developed a mathematical model which, for the first time, estimates the significance of asymptomatic infections in malaria transmission when looking at the distribution of the disease in different populations. They applied their model to data from hospital admissions of children with malaria, provided by researchers working in eight different regions in sub-Saharan Africa, where malaria is endemic.

The model shows that, contrary to what was previously thought, in regions of moderate transmission there is a threshold for malaria eradication, separating endemic and malaria-free states. Any intervention success depends critically on reducing occurrence of disease below this threshold, which the model predicts to be possible in areas of moderate transmission, which is the case for most of Africa.

... more about:
»Disease »Malaria »Transmission »endemic

Industrialised nations sit well below this threshold, in the malaria-free state, since the number of clinically immune people is extremely low, making any re-emergence of malaria in these countries highly improbable.

Ricardo Águas, first author of the paper, says, “This is a very powerful model, since it should allow us to determine quantifiable targets for reducing transmission of malaria (by providing mosquito nets, for example) and for fighting the disease (through mass- handing out of anti-malaria drugs), for a specific region.”

Gabriela Gomes added, “Huge efforts are being put into fighting malaria in developing countries. Our model presents a very optimistic outlook for eradicating the disease in areas where it is moderately endemic, contrary to current thinking. We are now looking for research partners who may provide us with more clinical data, from more regions in Africa, which we could use to strengthen our model, and feed into effective eradication programmes.”

Contact:
Gabriela Gomes
Email: ggomes@igc.gulbenkian.pt
Citation: Águas R, White LJ, Snow RW, Gomes MGM (2008) Prospects for Malaria Eradication in Sub-Saharan Africa. PLoS ONE 3(3): e1767. doi:10.1371/journal.pone.0001767

Rebecca Walton | alfa
Further information:
http://www.plosone.org/doi/pone.0001767

Further reports about: Disease Malaria Transmission endemic

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>