Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Increased Level Of Magnetic Iron Oxides Found In Alzheimer’s Disease

10.03.2008
A team of scientists, led by Professor Jon Dobson, of Keele University in Staffordshire, UK, have found, for the first time, raised levels of magnetic iron oxides in the part of the brain affected by Alzheimer's Disease (AD).

Their research has also shown that this association was particularly strong in females compared to males. The group speculates that this may be a result of gender differences in the way the body handles and stores iron.

Though the results are based on a small number of samples, they give an indication that iron accumulation associated with Alzheimer's appears to involve the formation of strongly magnetic iron compounds. As these compounds have a strong effect on MRI signal intensity, with further study, it may be possible to use this as a biomarker for the development of an MRI-based Alzheimer's diagnostic technique.

The research team also included Quentin Pankhurst, London Centre for Nanotechnology and Department of Physics & Astronomy, University College, London; Dimitri Hautot, Institute of Science and Technology in Medicine, Keele University, and Nadeem Khan, Department of Neuropathology, Institute of Psychiatry, King's College London.

... more about:
»Iron »associated »concentration »magnetite »subjects

The study looked at brain tissue from 11 Alzheimer’s Disease and 11 age-matched control subjects. It showed, for the first time, that the total concentration of biogenic magnetite is generally higher in the Alzheimer brain (in some cases as much as 15 times greater than controls) and that there are gender-based differences, with Alzheimer’s Disease with female subjects having significantly higher concentrations than all other groups.

Professor Dobson said: “Iron accumulation and dysregulation of iron transport and storage has been found to be associated with many other neurodegenerative conditions, such as Parkinson’s disease, Huntington’s disease (HD), multiple sclerosis and Amyotrophic Lateral Sclerosis. In recent years, a hereditary neurodegenerative disease, neuroferritinopathy, has been linked to a mutation in the gene encoding for the ferritn light polypeptide. This direct link between neurodegeneration in the basal ganglia and ferritin, the body’s primary iron storage protein, results in the accumulation of iron in the brain and symptoms similar to HD.

“There is still little known about the chemical form of iron associated with these diseases, its role in neurodegeneration (if any) and its origin. Investigations of brain iron based on histochemical staining techniques have generally ignored its chemical state.”

This study shows a clear correlation in the concentration and the size of the biogenic magnetite in both the Alzheimer disease and control groups. It is also notable that the largest magnetite concentrations and smallest particles are all from Alzheimer disease subjects, and that the data from the control subjects follow the same trend. This implies that the genesis of the biogenic magnetite may be the same in all cases, but that in Alzheimer Disease it may be more indicative of an accelerated process.

Professor Dobson added: “We speculate that magnetite formation within the ferritin core may occur generally in the brain, perhaps associated with aging, and that the process may become abnormal and uncontrolled in the Alzheimer brain. At this stage, this should be considered a working hypothesis and needs to be examined in larger studies. It appears, however, that elevated levels of magnetic iron oxides, which include reactive Fe2+, are present in AD tissue, a finding that lends weight to the suggestion that redox-active iron may play a role in neurodegenerative disease."

This work was supported by the UK Medical Research Council and National Institutes of Health.

A paper on the study, Increased Levels of Magnetic Compunds in Alzheimer’s Disease, is scheduled for publication in the Journal of Alzheimer's Disease (Volume 13:1).

Chris Stone | alfa
Further information:
http://www.keele.ac.uk

Further reports about: Iron associated concentration magnetite subjects

More articles from Life Sciences:

nachricht Full of hot air and proud of it
18.04.2018 | University of Pittsburgh

nachricht Keeping the excitement under control
18.04.2018 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

Im Focus: Stronger evidence for a weaker Atlantic overturning

The Atlantic overturning – one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards – is weaker today than any time before in more than 1000 years. Sea surface temperature data analysis provides new evidence that this major ocean circulation has slowed down by roughly 15 percent since the middle of the 20th century, according to a study published in the highly renowned journal Nature by an international team of scientists. Human-made climate change is a prime suspect for these worrying observations.

“We detected a specific pattern of ocean cooling south of Greenland and unusual warming off the US coast – which is highly characteristic for a slowdown of the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

New capabilities at NSLS-II set to advance materials science

18.04.2018 | Materials Sciences

Strong carbon fiber artificial muscles can lift 12,600 times their own weight

18.04.2018 | Materials Sciences

Polymer-graphene nanocarpets to electrify smart fabrics

18.04.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>