Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

‘Invisible’ bacteria dupe the human immune system

20.02.2008
Scientists at the University of York have characterised an important new step in the mechanism used by bacteria to evade our immune system.

It is an ‘invisibility cloak’ which means that bacteria like Haemophilus influenzae, a common cause of ear infections in children, can move about the body without the risk of being attacked by the immune system.

A multidisciplinary research team from the Departments of Biology and Chemistry at York have been studying how bacteria capture the molecule used to make the ‘cloak’, called sialic acid.

The researchers have now discovered an enzymatic activity that helps in the more efficient capture of sialic acids released from our cell surfaces. As well as using the sialic acid to make the ‘invisibility cloak’ other bacteria use similar methods to capture sialic acid as a simple food source, so are literally eating us from the inside!

... more about:
»acid »bacteria »immune »sialic

The research is published in the latest issue of the Journal of Biological Chemistry.

Dr Gavin Thomas, of the Department of Biology, who led the research said: "This novel enzyme, as well as other steps required for the formation of the 'invisibility cloak' that we have discovered in York, now offers the chance to develop novel antimicrobials against these bacteria."

The work, which was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), was undertaken by Dr. Emmanuele Severi (Biology - Thomas lab) in collaboration with Dr. Jennifer Potts (Biology and Chemistry), Dr. Andrew Leech (Biology) and Professor Keith Wilson and Dr. Axel Müller (Chemistry and York Structural Biology Laboratory).

The team used the Centre for Magnetic Resonance based in the Department of Chemistry, and the Technology Facility in the Department of Biology.

David Garner | alfa
Further information:
http://www.york.ac.uk/admin/presspr/pressreleases/invisiblebacteria.htm

Further reports about: acid bacteria immune sialic

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>